Capsular Type and the Pneumococcal Human Host—Parasite Relationship

Recent evidence from epidemiological studies using both capsular typing and sequence-based genotyping suggests that capsular type rather than other genes, accounts for the biological properties of different pneumococcal serotypes. The authors have support from animal studies suggesting that the magn...

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Bibliographic Details
Published in:Clinical infectious diseases 2006-02, Vol.42 (4), p.460-462
Main Author: Crook, Derrick W.
Format: Article
Language:English
Subjects:
Antigens, Bacterial - immunology
Bacterial Capsules - immunology
Bacterial Typing Techniques
Children & youth
Comorbidity
Host-Parasite Interactions - genetics
Host-Parasite Interactions - immunology
Humans
Immunization, Passive
Pneumococcal Infections - microbiology
Pneumococcal Infections - prevention & control
Pneumococcal Vaccines - immunology
Pneumonia
Population
Streptococcus pneumoniae - genetics
Streptococcus pneumoniae - pathogenicity
Studies
Transformation, Bacterial - genetics
Virulence - genetics
Virulence - immunology
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Summary:Recent evidence from epidemiological studies using both capsular typing and sequence-based genotyping suggests that capsular type rather than other genes, accounts for the biological properties of different pneumococcal serotypes. The authors have support from animal studies suggesting that the magnitude and type of adaptive immune response in mice also correlated to the disease manifestations they observed [9]. Horizontal transfer of multiple penicillin-binding protein genes, and capsular biosynthetic genes, in natural populations of Streptococcus pneumoniae. The influence of mutation, recombination, population history, and selection on patterns of genetic diversity in Neisseria meningitidis.
ISSN:1058-4838
1537-6591
DOI:10.1086/499248