Effects of clopidogrel on survival of rat skin flaps

Summary Clopidogrel is a thienopyridine derivative that is chemically related to ticlopidine, which irreversibly inhibits platelet aggregation by selectively binding to adenylate cyclase-coupled adenosine diphosphate receptors on the platelet's surface. In animal models, clopidogrel has been sh...

Full description

Saved in:
Bibliographic Details
Published in:Journal of plastic, reconstructive & aesthetic surgery reconstructive & aesthetic surgery, 2007-01, Vol.60 (8), p.861-863
Main Authors: Ersoy, Atilla, Sevin, Kutlu, Sevin, Asuman, Serel, Savaş
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Clopidogrel
Flap survival
Graft Survival - drug effects
Graft Survival - physiology
Male
Medical sciences
Necrosis
Plastic Surgery
Platelet Aggregation Inhibitors - pharmacology
Random Allocation
Rat skin flap
Rats
Rats, Wistar
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgical Flaps - pathology
Ticlopidine - analogs & derivatives
Ticlopidine - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Clopidogrel is a thienopyridine derivative that is chemically related to ticlopidine, which irreversibly inhibits platelet aggregation by selectively binding to adenylate cyclase-coupled adenosine diphosphate receptors on the platelet's surface. In animal models, clopidogrel has been shown to reduce the incidence of both arterial and venous thrombi. In the present study the effects of clopidogrel on the survival of rat epigastric island flaps was researched. Epigastric island flaps of 7 × 7 cm were raised from symphisis pubis to arcus costa with the panniculus carnosus. The experimental group received seven doses of 25 mg/kg clopidogrel postoperatively, the first dose given immediately after the suturing of the flaps. The rats were anaesthetised on postoperative day 7 to assess the survival of flaps. The difference between the clopidogrel and the control group was significant ( P < 0.005). The full-thickness skin samples obtained after the calculation of survival percentages revealed thinning of the epidermis layer and active chronic inflammation in both groups. However, diffuse dilated vessels, extravasated eritrocytes were seen in the clopidogrel group flaps. The results indicated a significant increase in flap survival in rats given clopidogrel. Further research is needed to assess the critical doses of clopidogrel to create optimal flap survival improvement.
ISSN:1748-6815
1878-0539
DOI:10.1016/j.bjps.2007.02.001