Importance of 5‐hydroxytryptamine receptors on intestinal afferents in the regulation of visceral sensitivity

Serotonin (5‐HT) plays an important role as a signalling molecule in the gastrointestinal (GI) tract. The regulation of GI sensitivity via 5‐HT is mediated by specific 5‐HT receptor subytypes on intrinsic and extrinsic afferents. This review discusses visceral afferent hypersensitivity in irritable...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2007-08, Vol.19 (s2), p.13-18
Main Author: Greenwood‐van Meerveld, B.
Format: Article
Language:English
Subjects:
abdominal pain
Animals
colon
Enteric Nervous System - anatomy & histology
Enteric Nervous System - physiology
Humans
hypersensitivity
Intestines - innervation
Intestines - metabolism
irritable bowel syndrome
Irritable Bowel Syndrome - physiopathology
nerve
Protein Isoforms - metabolism
Receptors, Serotonin - metabolism
serotonin
Serotonin - metabolism
Signal Transduction - physiology
Visceral Afferents - metabolism
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Summary:Serotonin (5‐HT) plays an important role as a signalling molecule in the gastrointestinal (GI) tract. The regulation of GI sensitivity via 5‐HT is mediated by specific 5‐HT receptor subytypes on intrinsic and extrinsic afferents. This review discusses visceral afferent hypersensitivity in irritable bowel syndrome (IBS) and the importance of 5HT3, 5HT4, and 5HT2B receptor‐mediated mechanisms in the regulation of visceral sensitivity.
ISSN:1350-1925
1365-2982
DOI:10.1111/j.1365-2982.2007.00964.x