Prognostic factors in head and neck adenoid cystic carcinoma

The aim of this study was to analyse the clinical, histological and immunohistochemical prognostic factors of a large series of adenoid cystic carcinoma, using univariate and multivariate survival analyses. All cases of head and neck ACC ( n = 129) treated in a single institution in Brazil, between...

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Bibliographic Details
Published in:Oral oncology 2006-02, Vol.42 (2), p.139-146
Main Authors: da Cruz Perez, Danyel Elias, de Abreu Alves, Fábio, Nobuko Nishimoto, Inês, de Almeida, Oslei Paes, Kowalski, Luiz Paulo
Format: Article
Language:English
Subjects:
Adenoid cystic carcinoma
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - metabolism
Carcinoma, Adenoid Cystic - pathology
Carcinoma, Adenoid Cystic - secondary
Carcinoma, Adenoid Cystic - therapy
Child
Epidemiologic Methods
Female
Head and neck
Head and Neck Neoplasms - pathology
Head and Neck Neoplasms - therapy
Humans
Immunohistochemistry
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Otorhinolaryngology. Stomatology
Prognosis
Prognostic factors
Salivary Gland Neoplasms - pathology
Salivary Gland Neoplasms - therapy
Salivary glands
Treatment Outcome
Tumor Suppressor Protein p53 - metabolism
Tumors
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Summary:The aim of this study was to analyse the clinical, histological and immunohistochemical prognostic factors of a large series of adenoid cystic carcinoma, using univariate and multivariate survival analyses. All cases of head and neck ACC ( n = 129) treated in a single institution in Brazil, between 1955 and 1997, were selected for the study. Univariate survival analysis revealed that age older than 45 years ( p = 0.04), period of complaints inferior to 18 months ( p = 0.007), presence of paresthesia ( p = 0.04), T stage ( p = 0.01), N stage ( p = 0.04), M stage ( p < 0.001), clinical stage ( p = 0.003), solid histological type ( p < 0.001), presence of residual tumor ( p < 0.001) and expression of p53 ( p = 0.08) correlated with a poor prognosis. In the multivariate survival analyses, clinical stage, solid histological subtype and increased expression of p53 were independent significant prognostic factors. According to our findings, clinical stage, solid growth pattern and expression of p53 were the most important prognostic factors in patients with ACC.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2005.06.024