Beer down-regulates activated peripheral blood mononuclear cells in vitro

Moderate consumption of alcoholic beverages is suggested to reduce cardiovascular risk. Within this context, most attention is drawn to antioxidant ingredients of wine, but also beer was found to be beneficial. Potential effects of three different types of beer including alcohol-free beer were inves...

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Bibliographic Details
Published in:International immunopharmacology 2006-03, Vol.6 (3), p.390-395
Main Authors: Winkler, C., Wirleitner, B., Schroecksnadel, K., Schennach, H., Fuchs, D.
Format: Article
Language:English
Subjects:
Anti-inflammatory action
Anti-Inflammatory Agents - pharmacology
Beer
Biological and medical sciences
Cells, Cultured
Dose-Response Relationship, Drug
Down-Regulation - drug effects
Down-Regulation - immunology
Humans
Immunity, Cellular - drug effects
Immunosuppression
Immunosuppressive Agents - pharmacology
Indoleamine (2,3)-dioxygenase
Interferon-gamma - metabolism
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - metabolism
Medical sciences
Neopterin
Neopterin - antagonists & inhibitors
Neopterin - biosynthesis
Pharmacology. Drug treatments
Phytohemagglutinins - pharmacology
Tryptophan
Tryptophan - antagonists & inhibitors
Tryptophan - metabolism
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Summary:Moderate consumption of alcoholic beverages is suggested to reduce cardiovascular risk. Within this context, most attention is drawn to antioxidant ingredients of wine, but also beer was found to be beneficial. Potential effects of three different types of beer including alcohol-free beer were investigated using freshly isolated human peripheral blood mononuclear cells stimulated with the mitogen phytohaemagglutinin in vitro. Neopterin production and tryptophan degradation were monitored in culture supernatants to determine effects of test substances on immunobiochemical pathways induced by interferon-γ. In a subgroup of experiments also production of interferon-γ was measured. Compared to unstimulated cells, phytohaemagglutinin increased production of neopterin and also triggered the degradation of tryptophan (all p
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2005.09.002