Single nucleotide polymorphism (SNP) markers for benzimidazole resistance in veterinary nematodes

Resistance to the benzimidazole class of anthelmintics in nematodes of veterinary importance has a long history. Research into the mechanisms responsible for this resistance is subsequently at a more advanced stage than for other classes of anthelmintics. The principal mechanism of resistance to ben...

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Bibliographic Details
Published in:Parasitology 2007-01, Vol.134 (8), p.1077-1086
Main Authors: VON SAMSON-HIMMELSTJERNA, G., BLACKHALL, W. J., McCARTHY, J. S., SKUCE, P. J.
Format: Article
Language:English
Subjects:
Amino acids
animal parasitic nematodes
Animals
anthelmintic resistance
anthelmintics
Anthelmintics - pharmacology
Antiparasitic agents
benzimidazole
Benzimidazoles - pharmacology
beta-tubulin
Biological and medical sciences
Cyathostominae
Drug resistance
Drug Resistance - genetics
Fundamental and applied biological sciences. Psychology
General aspects
General aspects and techniques. Study of several systematic groups. Models
Genetic Markers
hookworms
Invertebrates
Investigations
literature reviews
Nemathelminthia. Plathelmintha
Nematoda - drug effects
Nematoda - genetics
Nematoda - physiology
Nematodes
point mutation
Polymorphism
Polymorphism, Single Nucleotide - genetics
Population genetics
resistance mechanisms
single nucleotide polymorphism
Studies
Trichostrongylidae
tubulin
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Summary:Resistance to the benzimidazole class of anthelmintics in nematodes of veterinary importance has a long history. Research into the mechanisms responsible for this resistance is subsequently at a more advanced stage than for other classes of anthelmintics. The principal mechanism of resistance to benzimidazoles is likely to involve changes in the primary structure of β-tubulins, the building blocks of microtubules. Specifically, point mutations in the β-tubulin isotype 1 gene leading to amino acid substitutions in codons 167, 198, and 200 of the protein have been associated with resistance in nematodes. These single nucleotide polymorphisms offer a means of detecting the presence of resistance within populations. In this mini-review, we focus on the prevalence and importance of these polymorphisms in three groups of nematodes: trichostrongylids, cyathostomins, and hookworms. A brief overview of existing strategies for genotyping single nucleotide polymorphisms is also presented. The CARS initiative hopes to exploit these known polymorphisms to further our understanding of the phenomenon of BZ resistance.
ISSN:0031-1820
1469-8161
DOI:10.1017/S0031182007000054