Sensation and distribution of stress and deformation in the human oesophagus

Evaluation of the distribution of stresses and strains in relation to distension‐induced sensation in the human oesophagus is valuable for understanding oesophageal biomechanics and mechano‐sensation. In 12 healthy volunteers a specially designed oesophageal bag containing an endoscopic ultrasound p...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2006-02, Vol.18 (2), p.104-114
Main Authors: Frøkjær, J. B., Andersen, S. D., Lundbye‐christensen, S., Funch‐jensen, P., Drewes, A. M., Gregersen, H.
Format: Article
Language:English
Subjects:
Adult
Biomechanical Phenomena
biomechanics
Butylscopolammonium Bromide - pharmacology
Catheterization
deformation
Dilatation
Esophagus - drug effects
Esophagus - physiology
Female
Humans
Male
mechano‐sensation
Middle Aged
Muscarinic Antagonists - pharmacology
Muscle, Smooth - drug effects
Muscle, Smooth - physiology
oesophagus
Sensation - physiology
Stress, Mechanical
Ultrasonics
ultrasound
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Summary:Evaluation of the distribution of stresses and strains in relation to distension‐induced sensation in the human oesophagus is valuable for understanding oesophageal biomechanics and mechano‐sensation. In 12 healthy volunteers a specially designed oesophageal bag containing an endoscopic ultrasound probe was inflated to the moderate pain level. Ultrasound images, bag pressure and perceived sensation were recorded before and after pharmacological relaxation of the smooth muscle with butylscopolamine. The oesophagus was assumed to be circular and thick‐walled. Distension induced a tensile circumferential stretch, radial compression and longitudinal shortening. Both circumferential strain and stress were highest at the mucosal surface and decreased throughout the wall. The stiffness increased throughout the wall and was highest at the outer surface (P 
ISSN:1350-1925
1365-2982
DOI:10.1111/j.1365-2982.2005.00734.x