Prevalence and risk factors of non-alcoholic fatty liver disease in potential living liver donors in Korea: A review of 589 consecutive liver biopsies in a single center

• Published in: Journal of hepatology 2007-08, Vol.47 (2), p.239-244
• Main Authors: Lee, Ji Young, Kim, Kang Mo, Lee, Sung Gyu, Yu, Eunsil, Lim, Young-Suk, Lee, Han Chu, Chung, Young-Hwa, Lee, Yung Sang, Suh, Dong-Jin
• Format: Article
• Language: English
• Subjects: Adult; Age Factors; Biological and medical sciences; Fatty Liver - diagnosis; Fatty Liver - epidemiology; Fatty Liver - etiology; Female; Gastroenterology and Hepatology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Hypertriglyceridemia - complications; Korea - epidemiology; Liver biopsy; Liver donor; Liver Transplantation; Liver, biliary tract, pancreas, portal circulation, spleen; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Living Donors - statistics & numerical data; Male; Medical sciences; Metabolic diseases; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Obesity; Obesity - complications; Other diseases. Semiology; Preoperative Care; Prevalence; Risk Factors; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Tomography, X-Ray Computed; Ultrasonography
• ISSN: 0168-8278; 1600-0641
• DOI: 10.1016/j.jhep.2007.02.007

Background/Aims The aim of the study was to evaluate the prevalence and risk factors of biopsy-proven non-alcoholic fatty liver disease (NAFLD) in potential living liver donors and to evaluate the efficacy of imaging techniques for the detection of steatosis in donors. Methods We reviewed the results of liver biopsy, ultrasonography (USG) and computed tomography (CT) and biochemical data performed in 589 consecutive potential liver donors as a pretransplantation work up from July 2004 to September 2005 at Asan Medical Centre. Results Of 589 participants, 408 (69.3%) were men, with a mean age of 31.1 ± 9.5 years. NAFLD (⩾5% steatosis in biopsy) was diagnosed in 303 (51.4%); >30% steatosis in 61 (10.4%) and non-alcoholic steatohepatitis in 13 (2.2%). The independent risk factors for >30% steatosis were age over 30 (OR = 2.223; p = 0.014), obesity (OR = 5.320; p < 0.001) and hypertriglyceridemia (OR = 2.253; p = 0.019) by multivariate analysis. The sensitivity of USG and CT for detecting >30% steatosis was 92.3% and 64.1%, and positive predictive value was only 34.5% and 45.1%, respectively. Conclusions NAFLD was highly prevalent in potential living liver donors. The independent risk factors for significant steatosis were older age, obesity and hypertriglyceridemia. USG and CT had limitations in detecting significant steatosis in liver donors.