Hypoxia-sensitive molecules may modulate the development of atherosclerosis in sleep apnoea syndrome

Objectives:  Obstructive sleep apnoea hypopnoea syndrome (OSAHS) is associated with increased morbidity and mortality due to cardiovascular disease. In order to examine the association between OSAHS and cardiovascular disease, this study measured hypoxia‐inducible and atherosclerosis‐associated mole...

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Published in:Respirology (Carlton, Vic.) Vic.), 2006-01, Vol.11 (1), p.24-31
Main Authors: HAYASHI, Motonori, FUJIMOTO, Keisaku, URUSHIBATA, Kazuhisa, TAKAMIZAWA, Akemi, KINOSHITA, Osamu, KUBO, Keishi
Format: Article
Language:English
Subjects:
Analysis of Variance
atherosclerosis
Atherosclerosis - blood
Atherosclerosis - etiology
Atherosclerosis - physiopathology
C-Reactive Protein - metabolism
cardiovascular disease
Case-Control Studies
HSP70 Heat-Shock Proteins - metabolism
Humans
hypoxaemia
Hypoxia - blood
Hypoxia - etiology
Hypoxia - physiopathology
Intercellular Signaling Peptides and Proteins - metabolism
Linear Models
Male
Middle Aged
OSA
Polysomnography
Risk Factors
Severity of Illness Index
Sleep Apnea, Obstructive - complications
Thromboplastin - metabolism
vascular endothelium
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Summary:Objectives:  Obstructive sleep apnoea hypopnoea syndrome (OSAHS) is associated with increased morbidity and mortality due to cardiovascular disease. In order to examine the association between OSAHS and cardiovascular disease, this study measured hypoxia‐inducible and atherosclerosis‐associated molecules in the peripheral blood. Methods:  In this study peripheral blood was obtained early in the morning from 60 consecutive male patients with OSAHS (AHI ≥10 events/h) and 30 male control subjects without OSAHS (AHI
ISSN:1323-7799
1440-1843
DOI:10.1111/j.1440-1843.2006.00780.x