A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies

Near-infrared spectroscopy (NIRS) is a fast and non-destructive analytical method. Associated with chemometrics, it becomes a powerful tool for the pharmaceutical industry. Indeed, NIRS is suitable for analysis of solid, liquid and biotechnological pharmaceutical forms. Moreover, NIRS can be impleme...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2007-07, Vol.44 (3), p.683-700
Main Authors: Roggo, Yves, Chalus, Pascal, Maurer, Lene, Lema-Martinez, Carmen, Edmond, Aurélie, Jent, Nadine
Format: Article
Language:English
Subjects:
Analysis
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Chemometrics
Drug Design
Fundamental and applied biological sciences. Psychology
General pharmacology
Humans
Identification
Medical sciences
Near infrared spectroscopy
On-line
Pharmaceutical Preparations - analysis
Pharmaceuticals
Pharmacology. Drug treatments
Qualification
Quality control
Quantification
Spectroscopy, Near-Infrared
Technology, Pharmaceutical - methods
Technology, Pharmaceutical - trends
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Summary:Near-infrared spectroscopy (NIRS) is a fast and non-destructive analytical method. Associated with chemometrics, it becomes a powerful tool for the pharmaceutical industry. Indeed, NIRS is suitable for analysis of solid, liquid and biotechnological pharmaceutical forms. Moreover, NIRS can be implemented during pharmaceutical development, in production for process monitoring or in quality control laboratories.This review focuses on chemometric techniques and pharmaceutical NIRS applications. The following topics are covered: qualitative analyses, quantitative methods and on-line applications. Theoretical and practical aspects are described with pharmaceutical examples of NIRS applications.
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2007.03.023