Economic evaluation of targeted treatments of invasive aspergillosis in adult haematopoietic stem cell transplant recipients in the Netherlands: a modelling approach

• Published in: Journal of antimicrobial chemotherapy 2007-08, Vol.60 (2), p.385-393
• Main Authors: Ament, André J. H. A., Hübben, Mariette W. A., Verweij, Paul E., de Groot, Ronald, Warris, Adillia, Donnelly, J. Peter, Wout, Jan van ‘t, Severens, Johan L.
• Format: Article
• Language: English
• Subjects: Amphotericin B - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal Agents - economics; Antifungal Agents - therapeutic use; antifungal treatment; Aspergillosis - drug therapy; Aspergillosis - economics; Biological and medical sciences; Chemotherapy; Cost analysis; Cost-Benefit Analysis; cost-effectiveness; Costs and Cost Analysis; Data Interpretation, Statistical; Decision Trees; Drug Combinations; Echinocandins - economics; Echinocandins - therapeutic use; Fungal infections; Hematopoietic Stem Cell Transplantation; Human mycoses; Humans; Infectious diseases; Lipopeptides; Medical sciences; Miscellaneous mycoses; Models, Economic; Models, Statistical; Mycoses; Netherlands - epidemiology; Pharmacology. Drug treatments; probabilistic sensitivity analysis; Pyrimidines - economics; Pyrimidines - therapeutic use; Reproducibility of Results; Stem cells; Survival Analysis; Transplants & implants; Triazoles - economics; Triazoles - therapeutic use; Voriconazole
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/dkm196

Objectives The aim of this study was to assess the cost-effectiveness of a targeted treatment model of antifungal treatment strategies for adult haematopoietic stem cell transplant (HSCT) recipients in the Netherlands from a hospital perspective, using a decision analytic modelling approach. Methods The economic evaluation of desoxycholate amphotericin B, liposomal amphotericin B, voriconazole and caspofungin was undertaken. These drugs could be used alone, in various combinations or sequentially. In our model, first-line therapy consisted of either voriconazole or liposomal amphotericin B. If necessary, treatment was switched to a second-line treatment, including combination antifungal therapy. The theoretical population in this model consisted of adult HSCT recipients with proven or probable invasive aspergillosis (IA). Long-term survival was extrapolated from survival after 12 weeks of treatment and life expectancy. Results First-line antifungal treatment strategies with voriconazole were both more effective and less costly over first-line strategies employing liposomal amphotericin B at a dosage of 4 mg/kg/day. The strategy of voriconazole followed by caspofungin (voriconazole/caspofungin) was dominant over the strategies of voriconazole followed by liposomal amphotericin B (voriconazole/liposomal amphotericin B) or desoxycholate amphotericin B (voriconazole/desoxycholate amphotericin B). However, the voriconazole followed by the combination of liposomal amphotericin B and caspofungin strategy (voriconazole/liposomal amphotericin B + caspofungin) was more effective though more expensive than the voriconazole/caspofungin strategy resulting in an incremental cost-effectiveness ratio (ICER) of about €107 000 for a life-year saved. At a dosage of 1 mg/kg/day of liposomal amphotericin B, the voriconazole/caspofungin strategy was more effective but more costly than the voriconazole/desoxycholate amphotericin B strategy with an ICER of €10 000 for each extra life-year saved. Between the voriconazole/liposomal amphotericin B + caspofungin and the voriconazole/caspofungin strategies, the ICER was €40 000. Conclusions Probabilistic analyses on net monetary benefit showed that the voriconazole/caspofungin strategy had the highest probability of being the most cost-effective strategy.