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Tumor regression in mesorectal lymphnodes after neoadjuvant chemoradiation for rectal cancer
Abstract Aims The histological modification produced by neoadjuvant chemoradiation on primary rectal cancer has been investigated by many authors, and a prognostic value of tumor regression grade (TRG) has been identified. Tumor regression grade on metastatic mesorectal lymphnodes has been never eva...
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Published in: | European journal of surgical oncology 2007-08, Vol.33 (6), p.724-728 |
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description | Abstract Aims The histological modification produced by neoadjuvant chemoradiation on primary rectal cancer has been investigated by many authors, and a prognostic value of tumor regression grade (TRG) has been identified. Tumor regression grade on metastatic mesorectal lymphnodes has been never evaluated. The purpose of this study is to analyse the TRG on mesorectal lymphnodes (lymphnode regression grade, LRG) after preoperative chemoradiation in rectal cancer patients and to determine the correlation with TRG of primary tumor. Methods Surgical specimens from 35 patients who underwent chemoradiation were included. LRG on mesorectal lymphnodes was assessed by immunohistochemistry. Response to treatment was evaluated by a 5-point LRG based on the ratio of residual tumor to fibrosis. Results Complete pathologic response (LRG 1) was observed in 18 patients (51%). In 4 patients (11%) no regression was observed (LRG 5). In 4 cases only reactive lymphnodes were found. LRG on lymphnodes significantly correlated with TRG on primary tumor ( p < 0.05). Conclusions Neoadjuvant chemoradiation determines a tumor regression on mesorectal lymphnodes as on primary tumor; further studies are needed to evaluate the prognostic value of LRG. |
doi_str_mv | 10.1016/j.ejso.2007.01.023 |
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Tumor regression grade on metastatic mesorectal lymphnodes has been never evaluated. The purpose of this study is to analyse the TRG on mesorectal lymphnodes (lymphnode regression grade, LRG) after preoperative chemoradiation in rectal cancer patients and to determine the correlation with TRG of primary tumor. Methods Surgical specimens from 35 patients who underwent chemoradiation were included. LRG on mesorectal lymphnodes was assessed by immunohistochemistry. Response to treatment was evaluated by a 5-point LRG based on the ratio of residual tumor to fibrosis. Results Complete pathologic response (LRG 1) was observed in 18 patients (51%). In 4 patients (11%) no regression was observed (LRG 5). In 4 cases only reactive lymphnodes were found. LRG on lymphnodes significantly correlated with TRG on primary tumor ( p < 0.05). Conclusions Neoadjuvant chemoradiation determines a tumor regression on mesorectal lymphnodes as on primary tumor; further studies are needed to evaluate the prognostic value of LRG.</description><identifier>ISSN: 0748-7983</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1016/j.ejso.2007.01.023</identifier><identifier>PMID: 17336482</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Chemoradiation therapy ; Chemotherapy, Adjuvant ; Dose Fractionation ; Female ; Fibrosis ; Hematology, Oncology and Palliative Medicine ; Humans ; Lymph Nodes - pathology ; Lymphatic Metastasis - pathology ; Lymphatic Metastasis - prevention & control ; Lymphnode regression grade (LRG) ; Lymphnodes metastasis ; Male ; Mesorectum ; Neoadjuvant Therapy ; Neoplasm Staging ; Neoplasm, Residual - pathology ; Peritoneum ; Radiotherapy, Adjuvant ; Rectal cancer ; Rectal Neoplasms - pathology ; Rectal Neoplasms - surgery ; Rectum ; Remission Induction ; Retrospective Studies ; Surgery ; Treatment Outcome ; Tumor regression grade</subject><ispartof>European journal of surgical oncology, 2007-08, Vol.33 (6), p.724-728</ispartof><rights>2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-a2ad963fc55799efd98f0fbc9962cd85ba9a3a0fcd508cf49e0db20c4bf6d48e3</citedby><cites>FETCH-LOGICAL-c475t-a2ad963fc55799efd98f0fbc9962cd85ba9a3a0fcd508cf49e0db20c4bf6d48e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17336482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caricato, M</creatorcontrib><creatorcontrib>Ausania, F</creatorcontrib><creatorcontrib>De Dominicis, E</creatorcontrib><creatorcontrib>Vincenzi, B</creatorcontrib><creatorcontrib>Rabitti, C</creatorcontrib><creatorcontrib>Tonini, G</creatorcontrib><creatorcontrib>Cellini, F</creatorcontrib><creatorcontrib>Coppola, R</creatorcontrib><title>Tumor regression in mesorectal lymphnodes after neoadjuvant chemoradiation for rectal cancer</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>Abstract Aims The histological modification produced by neoadjuvant chemoradiation on primary rectal cancer has been investigated by many authors, and a prognostic value of tumor regression grade (TRG) has been identified. Tumor regression grade on metastatic mesorectal lymphnodes has been never evaluated. The purpose of this study is to analyse the TRG on mesorectal lymphnodes (lymphnode regression grade, LRG) after preoperative chemoradiation in rectal cancer patients and to determine the correlation with TRG of primary tumor. Methods Surgical specimens from 35 patients who underwent chemoradiation were included. LRG on mesorectal lymphnodes was assessed by immunohistochemistry. Response to treatment was evaluated by a 5-point LRG based on the ratio of residual tumor to fibrosis. Results Complete pathologic response (LRG 1) was observed in 18 patients (51%). In 4 patients (11%) no regression was observed (LRG 5). In 4 cases only reactive lymphnodes were found. LRG on lymphnodes significantly correlated with TRG on primary tumor ( p < 0.05). Conclusions Neoadjuvant chemoradiation determines a tumor regression on mesorectal lymphnodes as on primary tumor; further studies are needed to evaluate the prognostic value of LRG.</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Chemoradiation therapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Dose Fractionation</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Lymphatic Metastasis - prevention & control</subject><subject>Lymphnode regression grade (LRG)</subject><subject>Lymphnodes metastasis</subject><subject>Male</subject><subject>Mesorectum</subject><subject>Neoadjuvant Therapy</subject><subject>Neoplasm Staging</subject><subject>Neoplasm, Residual - pathology</subject><subject>Peritoneum</subject><subject>Radiotherapy, Adjuvant</subject><subject>Rectal cancer</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - surgery</subject><subject>Rectum</subject><subject>Remission Induction</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Tumor regression grade</subject><issn>0748-7983</issn><issn>1532-2157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp9kcFq3DAQhkVpaDZpX6CH4lNvdkeSbVlQCiW0SSCQQ9NbQcjSqJFrW1vJDuzbV84uFHroaS7_9zPzDSFvKVQUaPthqHBIoWIAogJaAeMvyI42nJWMNuIl2YGou1LIjp-Ti5QGAJBcyFfknArO27pjO_LjYZ1CLCL-jJiSD3Ph52LCFCKaRY_FeJj2j3OwmArtFozFjEHbYX3S81KYR8ywtl4vG-mei54xo2eD8TU5c3pM-OY0L8n3r18erm7Ku_vr26vPd6WpRbOUmmkrW-5M0wgp0VnZOXC9kbJlxnZNr6XmGpyxDXTG1RLB9gxM3bvW1h3yS_L-2LuP4feKaVGTTwbHUedt16QECGi7us1BdgyaGFKK6NQ--knHg6KgNqdqUJtTtTlVQFV2mqF3p_a1n9D-RU4Sc-DjMYD5xiePUSXjMQuwftOhbPD_7__0D25GP3ujx194wDSENc7ZnqIqMQXq2_bV7an5KIC65vwPHJKgGg</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Caricato, M</creator><creator>Ausania, F</creator><creator>De Dominicis, E</creator><creator>Vincenzi, B</creator><creator>Rabitti, C</creator><creator>Tonini, G</creator><creator>Cellini, F</creator><creator>Coppola, R</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Tumor regression in mesorectal lymphnodes after neoadjuvant chemoradiation for rectal cancer</title><author>Caricato, M ; Ausania, F ; De Dominicis, E ; Vincenzi, B ; Rabitti, C ; Tonini, G ; Cellini, F ; Coppola, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-a2ad963fc55799efd98f0fbc9962cd85ba9a3a0fcd508cf49e0db20c4bf6d48e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Chemoradiation therapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Dose Fractionation</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Lymphatic Metastasis - prevention & control</topic><topic>Lymphnode regression grade (LRG)</topic><topic>Lymphnodes metastasis</topic><topic>Male</topic><topic>Mesorectum</topic><topic>Neoadjuvant Therapy</topic><topic>Neoplasm Staging</topic><topic>Neoplasm, Residual - pathology</topic><topic>Peritoneum</topic><topic>Radiotherapy, Adjuvant</topic><topic>Rectal cancer</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - surgery</topic><topic>Rectum</topic><topic>Remission Induction</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Tumor regression grade</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caricato, M</creatorcontrib><creatorcontrib>Ausania, F</creatorcontrib><creatorcontrib>De Dominicis, E</creatorcontrib><creatorcontrib>Vincenzi, B</creatorcontrib><creatorcontrib>Rabitti, C</creatorcontrib><creatorcontrib>Tonini, G</creatorcontrib><creatorcontrib>Cellini, F</creatorcontrib><creatorcontrib>Coppola, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caricato, M</au><au>Ausania, F</au><au>De Dominicis, E</au><au>Vincenzi, B</au><au>Rabitti, C</au><au>Tonini, G</au><au>Cellini, F</au><au>Coppola, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor regression in mesorectal lymphnodes after neoadjuvant chemoradiation for rectal cancer</atitle><jtitle>European journal of surgical oncology</jtitle><addtitle>Eur J Surg Oncol</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>33</volume><issue>6</issue><spage>724</spage><epage>728</epage><pages>724-728</pages><issn>0748-7983</issn><eissn>1532-2157</eissn><abstract>Abstract Aims The histological modification produced by neoadjuvant chemoradiation on primary rectal cancer has been investigated by many authors, and a prognostic value of tumor regression grade (TRG) has been identified. Tumor regression grade on metastatic mesorectal lymphnodes has been never evaluated. The purpose of this study is to analyse the TRG on mesorectal lymphnodes (lymphnode regression grade, LRG) after preoperative chemoradiation in rectal cancer patients and to determine the correlation with TRG of primary tumor. Methods Surgical specimens from 35 patients who underwent chemoradiation were included. LRG on mesorectal lymphnodes was assessed by immunohistochemistry. Response to treatment was evaluated by a 5-point LRG based on the ratio of residual tumor to fibrosis. Results Complete pathologic response (LRG 1) was observed in 18 patients (51%). In 4 patients (11%) no regression was observed (LRG 5). In 4 cases only reactive lymphnodes were found. LRG on lymphnodes significantly correlated with TRG on primary tumor ( p < 0.05). Conclusions Neoadjuvant chemoradiation determines a tumor regression on mesorectal lymphnodes as on primary tumor; further studies are needed to evaluate the prognostic value of LRG.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17336482</pmid><doi>10.1016/j.ejso.2007.01.023</doi><tpages>5</tpages></addata></record> |
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subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Chemoradiation therapy Chemotherapy, Adjuvant Dose Fractionation Female Fibrosis Hematology, Oncology and Palliative Medicine Humans Lymph Nodes - pathology Lymphatic Metastasis - pathology Lymphatic Metastasis - prevention & control Lymphnode regression grade (LRG) Lymphnodes metastasis Male Mesorectum Neoadjuvant Therapy Neoplasm Staging Neoplasm, Residual - pathology Peritoneum Radiotherapy, Adjuvant Rectal cancer Rectal Neoplasms - pathology Rectal Neoplasms - surgery Rectum Remission Induction Retrospective Studies Surgery Treatment Outcome Tumor regression grade |
title | Tumor regression in mesorectal lymphnodes after neoadjuvant chemoradiation for rectal cancer |
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