The Metabolic Syndrome: Inflammation, Diabetes Mellitus, and Cardiovascular Disease

There is accumulating evidence that inflammation is an important risk factor in cardiovascular disease (CVD). Elevated levels of the inflammatory marker high-sensitivity C-reactive protein (hs-CRP) are associated with increased risk for CVD and diabetes mellitus. Adding hs-CRP to the definition of t...

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Bibliographic Details
Published in:The American journal of cardiology 2006-01, Vol.97 (2), p.3-11
Main Author: Haffner, Steven M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers - blood
C-Reactive Protein - metabolism
Cardiology. Vascular system
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - etiology
Diabetes
Diabetes Mellitus - blood
Diabetes Mellitus - etiology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Humans
Inflammation - blood
Medical sciences
Metabolic diseases
Metabolic Syndrome - blood
Metabolic Syndrome - complications
Miscellaneous
Other metabolic disorders
Proteins
Risk Factors
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Summary:There is accumulating evidence that inflammation is an important risk factor in cardiovascular disease (CVD). Elevated levels of the inflammatory marker high-sensitivity C-reactive protein (hs-CRP) are associated with increased risk for CVD and diabetes mellitus. Adding hs-CRP to the definition of the metabolic syndrome has been shown to improve the prediction of CVD. Elevated hs-CRP levels may also be predictive of development of the metabolic syndrome. Current definitions of the metabolic syndrome differ, and cardiovascular risk appears to differ according to which component risk factors are present. Further studies are required to identify a widely accepted criterion for the syndrome that will optimally predict the risk of diabetes and CVD. It is possible that such a definition will include a measure of inflammation.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.11.010