Solubilization of docetaxel in poly(ethylene oxide ) -block-poly (butylene /styrene oxide) micelles

Poly(ethylene oxide)-block-poly(styrene oxide) (PEO-b-PSO) and PEO-b-poly(butylene oxide) (PEO-b-PBO) of different chain lengths were synthesized and characterized for their self-assembling properties in water by dynamic/static light scattering, spectrofluorimetry, and transmission electron microsco...

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Bibliographic Details
Published in:Biomacromolecules 2007-07, Vol.8 (7), p.2250-2257
Main Authors: ELSABAHY, Mahmoud, PERRON, Marie-Eve, BERTRAND, Nicolas, YU, Ga-Er, LEROUX, Jean-Christophe
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Docetaxel
Epoxy Compounds - chemistry
Exact sciences and technology
General pharmacology
Medical sciences
Micelles
Microscopy, Electron, Transmission
Organic polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Polyenes - chemistry
Polyethylene Glycols - chemistry
Properties and characterization
Solubility
Solution and gel properties
Taxoids - chemistry
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Summary:Poly(ethylene oxide)-block-poly(styrene oxide) (PEO-b-PSO) and PEO-b-poly(butylene oxide) (PEO-b-PBO) of different chain lengths were synthesized and characterized for their self-assembling properties in water by dynamic/static light scattering, spectrofluorimetry, and transmission electron microscopy. The resulting polymeric micelles were evaluated for their ability to solubilize and protect the anticancer drug docetaxel (DCTX) from degradation. The drug release kinetics as well as the cytotoxicity of the loaded micelles were assessed in vitro. All polymers formed micelles with a highly viscous core at low critical association concentrations (
ISSN:1525-7797
1526-4602
DOI:10.1021/bm070226v