Difference in adhesion molecule expression (ICAM-1 and VCAM-1) in juvenile and adult dermatomyositis, polymyositis and inclusion body myositis

• Published in: Autoimmunity reviews 2006-02, Vol.5 (2), p.93-100
• Main Authors: Sallum, Adriana M.E., Kiss, Maria H.B., Silva, Clovis A.A., Wakamatsu, Alda, Vianna, Maria A.A.G., Sachetti, Silvana, Marie, Suely K.N.
• Format: Article
• Language: English
• Subjects: Adhesion molecules; Adult; Blood Vessels - chemistry; Blood Vessels - metabolism; Blood Vessels - pathology; Child; Dermatomyositis - metabolism; Dermatomyositis - pathology; Humans; ICAM-1; Inflammatory myopathies; Intercellular Adhesion Molecule-1 - analysis; Intercellular Adhesion Molecule-1 - metabolism; Muscle biopsy; Muscle Fibers, Skeletal - chemistry; Muscle Fibers, Skeletal - metabolism; Muscle Fibers, Skeletal - pathology; Myositis - metabolism; Myositis - pathology; Myositis, Inclusion Body - metabolism; Myositis, Inclusion Body - pathology; Polymyositis - metabolism; Polymyositis - pathology; Vascular Cell Adhesion Molecule-1 - analysis; Vascular Cell Adhesion Molecule-1 - metabolism; VCAM-1
• ISSN: 1568-9972; 1568-9972
• DOI: 10.1016/j.autrev.2005.05.008

To assess the differential expression of adhesion molecules ICAM-1 and VCAM-1 in vessels and muscle fibers in acquired inflammatory myopathy, a series comprising thirty-seven muscle biopsy specimens from patients with JDM, fifteen with DM, fifteen with PM and seven with IBM was studied. Histochemical and immunohistochemical tests (StreptABCcomplex/HRP) for ICAM-1 and VCAM-1 (Dakopatts) were performed in serial frozen sections. ICAM-1 expression in vessels was significantly ( p < 0.0001) more present in JDM than PM, DM or IBM. However, in muscle fibers, ICAM-1 expression was absent in both JDM and IBM, but present in 33.4% and 40% in PM and DM respectively ( p < 0.0001). VCAM-1 expression in vessels was significantly more present in PM and DM than JDM and IBM ( p < 0.0001) while VCAM-1 expression in muscle fibers was almost absent in the four groups ( p = 0.2632). These findings emphasize the importance of adhesion molecules in the pathophysiology of the inflammatory myopathies, mainly the marked ICAM-1 expression in vessels in JDM, corroborating the microvascular involvement in this disease. In contrast, VCAM-1 seems not to play a major role in JDM, as previously described in PM, DM and IBM. Adhesion molecule expression in JDM presents a differential characteristic when compared to PM, DM and IBM.