Androgenic juvenile granulosa cell tumor of the ovary with cystic presentation: a case report

Granulosa cell tumors account for approximately 1-2% of all ovarian tumors. There are two types: adult granulosa cell tumor and juvenile granulosa cell tumor. Juvenile granulosa cell tumors constitute 5% of this histological subtype, and the prognosis is good because the majority present as Stage I...

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Bibliographic Details
Published in:European journal of gynaecological oncology 2007, Vol.28 (3), p.236-238
Main Authors: Nomelini, R S, Micheletti, A M R, Adad, S J, Murta, E F C
Format: Article
Language:English
Subjects:
17-alpha-Hydroxyprogesterone - blood
Adolescent
Female
Granulosa Cell Tumor - blood
Granulosa Cell Tumor - pathology
Granulosa Cell Tumor - surgery
Humans
Ovarian Neoplasms - blood
Ovarian Neoplasms - pathology
Ovarian Neoplasms - surgery
Testosterone - blood
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Summary:Granulosa cell tumors account for approximately 1-2% of all ovarian tumors. There are two types: adult granulosa cell tumor and juvenile granulosa cell tumor. Juvenile granulosa cell tumors constitute 5% of this histological subtype, and the prognosis is good because the majority present as Stage I tumors. The treatment can consist of conservative surgery. Androgen production is rare and produces virilization in women. These tumors are usually solid or predominantly solid. We describe the case of a 13-year-old girl with androgenic manifestations and increased abdominal size. Her plasma testosterone level was elevated. A left adnexal cyst (14.4 x 9.1 x 9.7 cm) was revealed at pelvic ultrasonography. The patient underwent an exploratory laparotomy, revealing a left ovarian cystic tumor. Diagnosis was juvenile granulosa cell tumor.
ISSN:0392-2936