Rosiglitazone Reduces the Evolution of Experimental Periodontitis in the Rat

The peroxisome proliferator-activated receptor-γ (PPAR-γ) receptor appears to play a pivotal role in the regulation of cellular proliferation and inflammation. Recent evidence also suggests that rosiglitazone, a PPAR-γ agonist, reduces acute and chronic inflammation. We hypothesized that rosiglitazo...

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Published in:Journal of dental research 2006-02, Vol.85 (2), p.156-161
Main Authors: Di Paola, R., Mazzon, E., Maiere, D., Zito, D., Britti, D., De Majo, M., Genovese, T., Cuzzocrea, S.
Format: Article
Language:English
Subjects:
Alveolar Bone Loss - drug therapy
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Dentistry
Ligation
Male
Neutrophil Infiltration - drug effects
Nitric Oxide Synthase Type II - antagonists & inhibitors
Periodontitis - drug therapy
Periodontitis - metabolism
Poly(ADP-ribose) Polymerase Inhibitors
PPAR gamma - agonists
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species - metabolism
Thiazolidinediones - pharmacology
Thiazolidinediones - therapeutic use
Tyrosine - analogs & derivatives
Tyrosine - antagonists & inhibitors
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Summary:The peroxisome proliferator-activated receptor-γ (PPAR-γ) receptor appears to play a pivotal role in the regulation of cellular proliferation and inflammation. Recent evidence also suggests that rosiglitazone, a PPAR-γ agonist, reduces acute and chronic inflammation. We hypothesized that rosiglitazone would attenuate periodontal inflammation. In the present study, we investigated the effects of rosiglitazone in a rat model of ligature-induced periodontitis. At day 8, ligation significantly induced an increase in neutrophil infiltration, as well as of gingivomucosal tissue expression of iNOS, nitrotyrosine formation, and poly (ADP-ribose) polymerase activation. Ligation significantly increased Evans blue extravasation in gingivomucosal tissue and alveolar bone destruction. Intraperitoneal injection of rosiglitazone (10 mg/kg 10% DMSO daily for 8 days) significantly decreased all of the parameters of inflammation, as described above. Analysis of these data demonstrated that rosiglitazone exerted an anti-inflammatory role during experimental periodontitis, and was able to ameliorate the tissue damage associated with ligature-induced periodontitis.
ISSN:0022-0345
1544-0591
DOI:10.1177/154405910608500208