Mitochondrial membrane fluidity, potential, and calcium transients in the myocardium from acute diabetic rats

In this study, we report for the first time concurrent measurements of membrane potential and dynamics and respiratory chain activities in rat heart mitochondria, as well as calcium transients in the hearts of rats in an early phase of streptozotocin diabetes, not yet accompanied with diabetes-induc...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2007-03, Vol.85 (3-4), p.372-381
Main Authors: WACZULIKOVA, Iveta, HABODASZOVA, Dana, CAGALINEC, Michal, FERKO, Miroslav, ULICNA, Olga, MATEASIK, Anton, SIKUROVA, Libusa, ZIEGELHÖFFER, Attila
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcium - physiology
Cells, Cultured
Complications and side effects
Diabetes
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - physiopathology
Evaluation
Fundamental and applied biological sciences. Psychology
Health aspects
Heart
Heart - physiopathology
Heart Ventricles - cytology
Male
Membrane Fluidity
Membrane Potential, Mitochondrial
Membrane potentials
Mitochondria, Heart - physiology
Mitochondrial membranes
Mitochondrial Membranes - physiology
Myocardium - metabolism
Myocytes, Cardiac - metabolism
Oxidative Phosphorylation
Oxygen Consumption
Properties
Rats
Rats, Wistar
Streptozocin
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:In this study, we report for the first time concurrent measurements of membrane potential and dynamics and respiratory chain activities in rat heart mitochondria, as well as calcium transients in the hearts of rats in an early phase of streptozotocin diabetes, not yet accompanied with diabetes-induced complications. Quantitative relationships among these variables were assessed. The mitochondria from diabetic rats exhibited decreased fluorescence anisotropy values of diphenylhexatriene. This indicates that hydrophobic core of the membranes was more fluid compared with controls (p
ISSN:0008-4212
1205-7541
DOI:10.1139/Y07-035