Relationship of HLA Antigens and Cryoglobulinaemia in Hepatitis C virus Infected Patients

To find the relationship between human leukocyte antigens (HLA) and cryoglobulin positivity in hepatitis C virus (HCV) infected individuals. Eligible individuals selected from pre and post renal transplant settings were divided into three groups. Group A (n = 301) consisted of normal controls, while...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2007-06, Vol.57 (6), p.300-305
Main Authors: ANIS, Sabiha, MUZAFFAR, Rana, MIRZA NAQI ZAFAR, AHMED, Ejaz, FATIMA, Kiran, SYED ALI ANWAR NAQVI, SYED ADIBUL HASAN RIZVI
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Case-Control Studies
Cryoglobulinemia - genetics
Cryoglobulinemia - immunology
Disease Susceptibility
Female
General aspects
Hepacivirus - genetics
Hepacivirus - immunology
Hepatitis C - genetics
Hepatitis C - immunology
HLA Antigens - blood
Humans
Male
Medical sciences
Polymerase Chain Reaction
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Summary:To find the relationship between human leukocyte antigens (HLA) and cryoglobulin positivity in hepatitis C virus (HCV) infected individuals. Eligible individuals selected from pre and post renal transplant settings were divided into three groups. Group A (n = 301) consisted of normal controls, while group B (n = 200) comprised of pathological controls that were HCV antibody (anti-HCV) positive but negative for cryoglobulins. Group C comprised of 56 anti-HCV positive, cryoglobulin positive patients. HLA-A, -B and -DRB1 loci were typed by polymerase chain reaction (PCR) method and relationship between HLA antigens, anti-HCV status and cryoglobulinaemia was analyzed. HLA-A*02, -B*57 and -DRB1*03 were more frequently found among group C members as compared to groups A and B. Only HLA-B* 57 occurrence reached statistical significance (14.3% versus 6% and 4%, corrected P-value = 0.045 and 0.012 and OR = 2.6 and 4 respectively) No differences in the distribution of HLA antigens were seen among healthy and pathological controls. The presence of HLA-B*57 confers susceptibility to cryoglobulinaemia in HCV infected patients in our population. HCV positive renal transplant recipients with these alleles should be monitored for cryoglobulin formation).
ISSN:0030-9982