Impact of Body Mass Index on Platelet Aggregation After Administration of a High Loading Dose of 600 mg of Clopidogrel Before Percutaneous Coronary Intervention

• Published in: The American journal of cardiology 2007-07, Vol.100 (2), p.203-205
• Main Authors: Sibbing, Dirk, MD, von Beckerath, Olga, MD, Schömig, Albert, MD, Kastrati, Adnan, MD, von Beckerath, Nicolas, MD
• Format: Article
• Language: English
• Subjects: Adenosine Diphosphate - pharmacology; Aged; Angioplasty, Balloon, Coronary; Biological and medical sciences; Body Mass Index; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Coronary heart disease; Diseases of the cardiovascular system; Drug dosages; Drug therapy; Female; Heart; Humans; Male; Medical sciences; Multivariate Analysis; Platelet Aggregation - drug effects; Platelet Aggregation - physiology; Platelet Aggregation Inhibitors - administration & dosage; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Ticlopidine - administration & dosage; Ticlopidine - analogs & derivatives; Weight
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2007.02.081

This study assessed the effect of body mass index (BMI) on platelet aggregation after administration of a high loading dose of clopidogrel 600 mg. Blood samples of 402 patients before percutaneous coronary intervention were collected ≥2 hours after administration of clopidogrel 600 mg. Platelet aggregation was measured in response to adenosine diphosphate (ADP; 5 and 20 μM). Patients were categorized as normal weight (BMI