Neurotrophins and schizophrenia

Abstract Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophr...

Full description

Saved in:
Bibliographic Details
Published in:Schizophrenia research 2007-08, Vol.94 (1), p.1-11
Main Authors: Buckley, Peter F, Mahadik, Sahebarao, Pillai, Anilkumar, Terry, Alvin
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Antipsychotic Agents - pharmacology
Antipsychotic Agents - therapeutic use
Binding Sites
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Brain - physiopathology
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - drug effects
Brain-Derived Neurotrophic Factor - metabolism
Humans
Medical sciences
Nerve Growth Factors - drug effects
Nerve Growth Factors - metabolism
Nerve Growth Factors - physiology
Neurotrophins
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Receptor, trkB - drug effects
Receptor, trkB - metabolism
Recurrence
Relapse
Schizophrenia
Schizophrenia - drug therapy
Schizophrenia - metabolism
Schizophrenia - physiopathology
Vascular Endothelial Growth Factor A - drug effects
Vascular Endothelial Growth Factor A - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia – as well as the propensity for progressive brain changes – there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2007.01.025