Respiratory symptoms, bronchial hyper-responsiveness, and eosinophilic airway inflammation in patients with moderate-to-severe atopic dermatitis

Summary Background Patients with atopic dermatitis (AD) often have symptoms suggestive of asthma or rhinitis. The prevalence and signs of respiratory disease in AD patients have been studied to a limited extent. Objectives To assess the prevalence and clustering of respiratory symptoms, bronchial hy...

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Bibliographic Details
Published in:Clinical and experimental allergy 2006-02, Vol.36 (2), p.192-197
Main Authors: Kyllönen, H., Malmberg, P., Remitz, A., Rytilä, P., Metso, T., Helenius, I., Haahtela, T., Reitamo, S.
Format: Article
Language:English
Subjects:
Adult
Allergic diseases
allergic rhinitis
asthma
Asthma - complications
Asthma - immunology
atopic dermatitis
Biological and medical sciences
brochial hyper-responsiveness
Bronchial Hyperreactivity
Case-Control Studies
Cross-Sectional Studies
Dermatitis, Atopic - complications
Dermatitis, Atopic - immunology
Eosinophilia - immunology
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunoglobulin E - blood
Immunopathology
Logistic Models
Male
Medical sciences
Respiratory Function Tests
serum immunoglobin E
Skin allergic diseases. Stinging insect allergies
skin prick tests
Sputum - immunology
sputum eosinophilia
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Summary:Summary Background Patients with atopic dermatitis (AD) often have symptoms suggestive of asthma or rhinitis. The prevalence and signs of respiratory disease in AD patients have been studied to a limited extent. Objectives To assess the prevalence and clustering of respiratory symptoms, bronchial hyper‐responsiveness (BHR), and eosinophilic airway inflammation in patients with moderate‐to‐severe AD. Methods Eighty‐six consecutive patients with moderate‐to‐severe AD and 49 randomly selected control subjects without AD were studied by questionnaire, flow volume spirometry, histamine challenge to detect BHR, induced sputum test to detect eosinophilic airway inflammation, and skin prick tests (SPTs) and total serum immunoglobulin (Ig)E measurements to detect atopy. Results The patients with AD showed increased risk of physician‐diagnosed asthma (36% vs. 2%, odds ratio (OR) 10.1, confidence interval (CI) 1.3–79.7, P=0.03), physician‐diagnosed allergic rhinitis (AR) (45% vs. 6%, OR 4.5, CI 1.2–16.7, P=0.02), BHR (51% vs. 10%, OR 5.5, CI 1.5–20.1, P=0.01), and sputum eosinophilia (81% vs. 11%, OR 76.1, CI 9.3‐623.5, P
ISSN:0954-7894
1365-2222
DOI:10.1111/j.1365-2222.2006.02419.x