Nontuberculous mycobacterial adenitis : Effectiveness of chemotherapy following incomplete excision

• Published in: Acta pædiatrica (Oslo) 2006-02, Vol.95 (2), p.182-188
• Main Authors: COULTER, J. Brian S, LLOYD, David A, JONES, Matthew, COOPER, John C, MCCORMICK, Maxwell S, CLARKE, Raymond W, TAWIL, Mohommed I
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - therapeutic use; Azithromycin - therapeutic use; Bacterial diseases; Biological and medical sciences; Child; Child, Preschool; Combined Modality Therapy; Extremities; Face; Female; General aspects; Human bacterial diseases; Humans; Infectious diseases; Knee; Lymphadenitis - drug therapy; Lymphadenitis - microbiology; Lymphadenitis - surgery; Male; Medical sciences; Miscellaneous; Mycobacterium - isolation & purification; Neck; Parotid Gland; Postoperative Care; Public health. Hygiene; Public health. Hygiene-occupational medicine; Rifabutin - therapeutic use; Time Factors; Tuberculosis and atypical mycobacterial infections; Wound Healing
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1080/08035250500331056

Management of lymphadenopathy caused by nontuberculous mycobacteria (NTM) is primarily surgical. Where this cannot achieve sufficient clearance of infected nodes, chemotherapy is often given. This study compared results of surgery alone with surgery followed by chemotherapy in instances where there was incomplete surgical removal of diseased tissue. Chemotherapy comprised azithromycin 10 mg/kg and rifabutin 6 mg/kg both given once daily for 6 mo. Ninety-eight children with NTM infection were seen in the period 1990-2004. Sixty-eight cases with adenopathy where "time to healing" (discharge stopped and inflammation settled) was known were available to compare response to treatment. The median (range) "time to healing" in weeks for 43 patients who had surgery alone was: incision and drainage (I&D)/curettage 6 (1-72) (n = 10); excision 3 (1-28) (n = 22); and from the last operation of multiple (repeat) surgery 3 (1-40) (n = 11). For 25 patients who required chemotherapy in addition to surgery, the median (range) "time to healing" in weeks was I&D/curettage 10 (1-40) (n = 17), excision 14 (8-20) (n = 2) and multiple surgery 29 (2-88) (n = 6). In children with adenitis due to NTM, where surgical resection is followed by continued discharge and inflammation, chemotherapy should be considered before further surgery is undertaken.