Nonmyeloablative Stem Cell Transplantation Is an Effective Therapy for Refractory or Relapsed Hodgkin Lymphoma: Results of a Spanish Prospective Cooperative Protocol

• Published in: Biology of blood and marrow transplantation 2006-02, Vol.12 (2), p.172-183
• Main Authors: Alvarez, Iván, Sureda, Anna, Caballero, Maria D., Urbano-Ispizua, Alvaro, Ribera, Josep M., Canales, Miguel, García-Conde, Javier, Sanz, Guillermo, Arranz, Reyes, Bernal, Maria T., de la Serna, Javier, Díez, José L., Moraleda, José M., Rubió-Félix, Daniel, Xicoy, Blanca, Martínez, Carmen, Mateos, Marivi V., Sierra, Jorge
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Allogeneic stem cell transplantation; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Disease-Free Survival; Female; Graft Survival; Graft vs Host Disease - mortality; Graft vs Host Disease - prevention & control; Hodgkin Disease - mortality; Hodgkin Disease - therapy; Humans; Male; Middle Aged; Prospective Studies; Recurrence; Reduced-intensity conditioning; Refractory or relapsed Hodgkin lymphoma; Spain; Stem Cell Transplantation - mortality; Survival Rate; Transplantation Conditioning - methods; Transplantation Conditioning - mortality; Transplantation, Homologous
• ISSN: 1083-8791; 1523-6536
• DOI: 10.1016/j.bbmt.2005.09.009

We report the results of reduced-intensity conditioning allogeneic stem cell transplantation (allo-RIC) in patients with advanced Hodgkin lymphoma (HL). Forty patients with relapsed or refractory HL were homogeneously treated with an RIC protocol (fludarabine 150 mg/m 2 intravenously plus melphalan 140 mg/m 2 intravenously) and cyclosporin A and methotrexate as graft-versus-host disease (GVHD) prophylaxis. Twenty-one patients (53%) had received >2 lines of chemotherapy, 23 patients (58%) had received radiotherapy, and 29 patients (73%) had experienced treatment failure with a previous autologous stem cell transplantation. Twenty patients (50%) were allografted in resistant relapse, and 38 patients received hematopoietic cells from an HLA-identical sibling. Five patients (12%) died from early transplant-related mortality (before day +100 after allo-RIC). One-year transplant-related mortality was 25%. Acute GVHD developed in 18 patients (45%). Chronic GVHD developed in 17 (45%) of the 31 evaluable patients. The response rate 3 months after the allo-RIC was 67% (21 [52%] complete remissions and 6 [15%] partial remissions). Eleven patients received donor lymphocyte infusions (DLIs) for disease relapse. The response rate after DLI was 54% (3 complete remissions and 3 partial remissions). Overall survival (OS) and progression-free survival (PFS) were 48% ± 10% and 32% ± 10% at 2 years, respectively. Refractoriness to chemotherapy was the only adverse prognostic factor for both OS (63% ± 12% versus 35% ± 13%; P = .05) and PFS (55% ± 16% versus 10% ± 9%; P = .006). For patients with failure of a prior autologous hematopoietic stem cell transplantation, results were especially good for those who experienced late relapses (≥12 months: 2-year OS and PFS were 75% ± 16% and 70% ± 18%, respectively). These data suggest that allo-RIC is feasible in heavily pretreated HL patients and has an acceptable early transplant-related mortality. Results are better in patients allografted in sensitive disease. Both responses observed after the development of GVHD and DLI may suggest a graft-versus-HL effect. Allo-RIC has to be considered an effective therapeutic approach for patients who have had treatment failure with a previous autologous hematopoietic stem cell transplantation.