integrated radiation hybrid map of bovine chromosome 18 that refines a critical region associated with multiple ocular defects in cattle

Congenital multiple ocular defects (MOD) of Japanese black cattle is a hereditary ocular disorder with an autosomal recessive mode of inheritance showing developmental defects of the lens, retina and iris, persistent embryonic eye vascularization and microphthalmia. The MOD locus has been mapped by...

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Bibliographic Details
Published in:Animal genetics 2006-02, Vol.37 (1), p.58-61
Main Authors: Abbasi, A.R, Geriletoya, Ihara, N, Khalaj, M, Sugimoto, Y, Kunieda, T
Format: Article
Language:English
Subjects:
Animals
beef cattle
BTA18
Cattle
cattle diseases
Cattle Diseases - genetics
Chromosomes, Mammalian - genetics
comparative map
comparative mapping
congenital abnormalities
DNA Primers
eye anomaly
eye diseases
Eye Diseases - genetics
Eye Diseases - veterinary
Gene Order - genetics
genes
Genes - genetics
genetic markers
inheritance (genetics)
linkage (genetics)
loci
microsatellite repeats
Microsatellite Repeats - genetics
molecular sequence data
physical chromosome mapping
radiation hybrid map
radiation hybrid mapping
Radiation Hybrid Mapping - veterinary
recessive genes
Wagyu
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Summary:Congenital multiple ocular defects (MOD) of Japanese black cattle is a hereditary ocular disorder with an autosomal recessive mode of inheritance showing developmental defects of the lens, retina and iris, persistent embryonic eye vascularization and microphthalmia. The MOD locus has been mapped by linkage analysis to a 6.6-cM interval on the proximal end of bovine chromosome 18, which corresponds to human chromosome 16q and mouse chromosome 8. To refine the MOD region in cattle, we constructed an integrated radiation hybrid (RH) map of the proximal region of bovine chromosome 18, which consisted of 17 genes and 10 microsatellite markers, using the SUNbRH₇₀₀₀ panel. Strong conservation of gene order was found among the corresponding chromosomal regions in cattle, human and mouse. The MOD-critical region was fine mapped to a 59.5-cR region that corresponds to a 6.3-Mb segment of human chromosome 16 and a 4.8-Mb segment of mouse chromosome 8. Several positional candidate genes, including FOXC2 and USP10, were identified in this region.
ISSN:0268-9146
1365-2052
DOI:10.1111/j.1365-2052.2005.01372.x