Bepridil Inhibits Sub-Acute Phase of Atrial Electrical Remodeling in Canine Rapid Atrial Stimulation Model

Background The effect of bepridil, a multichannel blocker, on atrial electrical remodeling was evaluated in a canine rapid atrial stimulation model. Methods and Results In 10 beagle dogs, the right atrial appendage (RAA) was paced at 400 beats/min for 2 weeks. The atrial electrophysiological paramet...

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Bibliographic Details
Published in:Circulation Journal 2006, Vol.70(2), pp.206-213
Main Authors: Sato, Daisuke, Niwano, Shinichi, Imaki, Ryuta, Masaki, Yoshihiko, Sasaki, Sae, Yuge, Masaru, Hirasawa, Shoji, Sasaki, Takeshi, Moriguchi, Masahiko, Niwano, Hiroe, Yoshimura, Hirokuni, Izumi, Tohru
Format: Article
Language:English
Subjects:
Animals
Atrial fibrillation
Bepridil
Bepridil - pharmacology
Calcium Channel Blockers - pharmacology
Dogs
Electrical remodeling
Heart Atria - physiopathology
Heart Conduction System - physiopathology
Models, Cardiovascular
Myocardial Contraction - drug effects
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Summary:Background The effect of bepridil, a multichannel blocker, on atrial electrical remodeling was evaluated in a canine rapid atrial stimulation model. Methods and Results In 10 beagle dogs, the right atrial appendage (RAA) was paced at 400 beats/min for 2 weeks. The atrial electrophysiological parameters, including effective refractory period (AERP), were evaluated at three atrial sites: RAA, the right atrium close to the inferior vena cava (IVC) and the left atrium (LA), during the time course of rapid pacing. Five of the dogs were given bepridil (10 mg · kg -1 · day-1 po). In the control group, AERP was significantly shortened at all atrial sites and the AERP shortening (ΔAERP) was larger for the RAA and LA than at the IVC site (p
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.70.206