The effect of mannitol on renal function following cardio‐pulmonary bypass in patients with normal pre‐operative creatinine

Summary Mannitol is often added to the cardiopulmonary bypass pump prime to reduce the incidence of renal dysfunction, but studies so far have been inconclusive. Urinary excretion of microalbumin and retinol binding protein are more sensitive than routine biochemical tests of renal function after ca...

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Bibliographic Details
Published in:Anaesthesia 2008-06, Vol.63 (6), p.576-582
Main Authors: Yallop, K. G., Sheppard, S. V., Smith, D. C.
Format: Article
Language:English
Subjects:
Acute Kidney Injury - prevention & control
Aged
Albuminuria - prevention & control
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthesiology
Biological and medical sciences
Cardiopulmonary Bypass
Creatinine - blood
Creatinine - urine
Double-Blind Method
Female
Heart surgery
Humans
Kidney - drug effects
Kidney - physiology
Male
Mannitol - therapeutic use
Medical research
Medical sciences
Middle Aged
Postoperative Complications - prevention & control
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Summary:Summary Mannitol is often added to the cardiopulmonary bypass pump prime to reduce the incidence of renal dysfunction, but studies so far have been inconclusive. Urinary excretion of microalbumin and retinol binding protein are more sensitive than routine biochemical tests of renal function after cardiac surgery. We performed a double‐blind, randomised, controlled trial in cardiac surgical patients with pre‐operative plasma creatinine
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.2008.05540.x