Pathologic evaluation of cryoprobe-assisted lumpectomy for breast cancer

Cryoprobe-assisted lumpectomy is a relatively new technique that converts nonpalpable carcinomas into well-defined, palpable ones by creating an ice ball under ultrasonographic guidance, thus eliminating the need for preoperative needle localization. We evaluated the effect of cryoprobe-induced free...

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Bibliographic Details
Published in:American journal of clinical pathology 2007-08, Vol.128 (2), p.239-244
Main Authors: SAHOO, Sunati, TALWALKAR, Sameer S, MARTIN, Alvin W, CHAGPAR, Anees B
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Breast Neoplasms - chemistry
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Cryosurgery
Female
Gynecology. Andrology. Obstetrics
Humans
Investigative techniques, diagnostic techniques (general aspects)
Ki-67 Antigen - analysis
Mammary gland diseases
Mastectomy, Segmental - methods
Medical sciences
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Receptors, Estrogen - analysis
Tumors
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Summary:Cryoprobe-assisted lumpectomy is a relatively new technique that converts nonpalpable carcinomas into well-defined, palpable ones by creating an ice ball under ultrasonographic guidance, thus eliminating the need for preoperative needle localization. We evaluated the effect of cryoprobe-induced freezing on tumor tissue, peritumoral tissue, and margin status in 6 cases of cryoprobe-assisted lumpectomy performed for infiltrating ductal carcinoma. Immunohistochemical stains for estrogen and progesterone receptors and the proliferation marker Ki-67 were performed on 4 cases and results compared with those of the pretreatment biopsy specimens. Although it was possible to recognize the tumor as infiltrating carcinoma in all cases, the alteration in tumor morphology interfered with tumor grading, distinguishing in situ and invasive components, and assessment of mitoses and lymphovascular invasion. The expression of estrogen and progesterone receptors was greatly reduced, whereas the Ki-67 staining was not significantly different when compared with pretreatment biopsy specimens. The "cryoprobe effect" did not interfere with evaluation of the margins and surrounding breast tissue.
ISSN:0002-9173
1943-7722
DOI:10.1309/67WLV9MFC72P7U8Q