Modulation of the endocrine and immune systems by well-controlled hyperthermia equipment

Since high levels of hyperthermia induce immunosuppression to a certain extent (i.e., granulocytosis and lymphocytopenia) in patients, we applied mild hyperthermia in volunteers using equipment enabling well-controlled hyperthermia. Restricted control of rectal temperature at 39.4 (± 0.2)°C for 30 m...

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Bibliographic Details
Published in:Biomedical Research 2007, Vol.28(3), pp.119-125
Main Authors: TOMIYAMA-MIYAJI, Chikako, WATANABE, Mayumi, OHISHI, Takahiko, KANDA, Yasuhiro, KAINUMA, Eisuke, BAKIR, Hanaa Y., SHEN, JiWei, REN, HongWei, INOUE, Masashi, TAJIMA, Keiho, BAI, XueFeng, ABO, Toru
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Adult
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
Blood Circulation - immunology
Body Temperature - immunology
Cells, Cultured
Fever - blood
Fever - immunology
Fever - pathology
Fever - physiopathology
Fever - therapy
Growth Hormone - blood
HLA-D Antigens - biosynthesis
HLA-D Antigens - genetics
Humans
Hydrocortisone - blood
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Lymphocyte Count
Middle Aged
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
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Summary:Since high levels of hyperthermia induce immunosuppression to a certain extent (i.e., granulocytosis and lymphocytopenia) in patients, we applied mild hyperthermia in volunteers using equipment enabling well-controlled hyperthermia. Restricted control of rectal temperature at 39.4 (± 0.2)°C for 30 min was conducted and various parameters of the body were examined. The most prominent change observed during exposure to hyperthermia was elevated levels of pH and PO2 in the blood, even in the venous blood. A transient elevation of ACTH, cortisol and growth hormone in the blood was also seen during this time. In parallel with this phenomenon, the number of total lymphocytes and those of its subsets (especially CD57+ or CD56+ NK cells and NKT cells) increased. More interestingly, the proportion of HLA-DR (MHC class II antigens) increased in NK and NKT cells, and their intensity on the surface of CD20+ B cells increased. These results suggest that mild hyperthermia is important for modulation of the functions of the circulatory, endocrine and immune systems.
ISSN:0388-6107
1880-313X
DOI:10.2220/biomedres.28.119