Bifunctional transition metal-based molecular catalysts for asymmetric syntheses

The discovery and development of conceptually new chiral bifunctional transition metal-based catalysts for asymmetric reactions is described. The chiral bifunctional Ru catalyst was originally developed for asymmetric transfer hydrogenation of ketones and imines and is now successfully applicable to...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2006, Vol.4 (3), p.393-406
Main Authors: Ikariya, Takao, Murata, Kunihiko, Noyori, Ryoji
Format: Article
Language:English
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Summary:The discovery and development of conceptually new chiral bifunctional transition metal-based catalysts for asymmetric reactions is described. The chiral bifunctional Ru catalyst was originally developed for asymmetric transfer hydrogenation of ketones and imines and is now successfully applicable to enantioselective C-C bond formation reaction with a wide scope and high practicability. The deprotonation of 1,3-dicarbonyl compounds with the chiral amido Ru complexes leading to the amine Ru complexes bearing C- or O-bonded enolates, followed by further reactions with electrophlies gives C-C bond formation products. The present bifunctional Ru catalyst offers a great opportunity to open up new fundamentals for stereoselective molecular transformation including enantioselective C-H and C-C as well as C-O, C-N bond formation.
ISSN:1477-0520
1477-0539
DOI:10.1039/b513564h