Risk of Switch in Mood Polarity to Hypomania or Mania in Patients With Bipolar Depression During Acute and Continuation Trials of Venlafaxine, Sertraline, and Bupropion as Adjuncts to Mood Stabilizers

OBJECTIVE: The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression. METHOD: One hundred fifty-nine patients with bipolar I disorder or bipolar II disorder partici...

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Bibliographic Details
Published in:The American journal of psychiatry 2006-02, Vol.163 (2), p.232-239
Main Authors: Leverich, Gabriele S., Altshuler, Lori L., Frye, Mark A., Suppes, Trisha, McElroy, Susan L., Keck, Paul E., Kupka, Ralph W., Denicoff, Kirk D., Nolen, Willem A., Grunze, Heinz, Martinez, Maria I., Post, Robert M.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Anticonvulsants - therapeutic use
Antidepressants
Antidepressive Agents - therapeutic use
Antipsychotic Agents - therapeutic use
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - diagnosis
Bipolar Disorder - drug therapy
Bipolar Disorder - epidemiology
Bipolar Disorder - psychology
Bipolar disorders
Bupropion - therapeutic use
Clinical trials
Cohort Studies
Cross-Sectional Studies
Cyclohexanols - therapeutic use
Drug therapy
Drug Therapy, Combination
Female
Humans
Lithium - therapeutic use
Male
Mania
Manic depression
Medical sciences
Mental health care
Mood disorders
Neuropharmacology
Patients
Pharmaceuticals
Pharmacology. Drug treatments
Psychiatric Status Rating Scales - statistics & numerical data
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Risk
Serotonin Uptake Inhibitors - therapeutic use
Sertraline - therapeutic use
Treatment Outcome
Venlafaxine Hydrochloride
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Summary:OBJECTIVE: The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression. METHOD: One hundred fifty-nine patients with bipolar I disorder or bipolar II disorder participated in a total of 228 acute (10-week) randomized trials of bupropion, sertraline, or venlafaxine as an adjunct to a mood stabilizer. Patients in 87 of these trials entered continuation treatment for up to 1 year. Antidepressant response and the occurrence of subthreshold brief hypomania (emergence of brief hypomania [at least 1 but
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.163.2.232