High-Throughput Screening for the Asymmetric Transformation Reaction of l-Histidine to d-Histidine by Capillary Array Electrophoresis

Asymmetric transformation reaction of l-histidine to d-histidine was studied by homemade capillary array electrophoresis for the first time. The enantiomeric excess value of asymmetric histidine products can be directly determined from the electrophoretogram of capillary array electrophoresis. The e...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2006-02, Vol.78 (3), p.901-904
Main Authors: Wang, Jun, Liu, Kaiying, Sun, Guangming, Bai, Jiling, Wang, Li
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
Analytical chemistry
Catalysis
Chemistry
Chromatographic methods and physical methods associated with chromatography
Electrophoresis, Capillary - instrumentation
Exact sciences and technology
Histidine - chemistry
Other chromatographic methods
Sensitivity and Specificity
Stereoisomerism
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Summary:Asymmetric transformation reaction of l-histidine to d-histidine was studied by homemade capillary array electrophoresis for the first time. The enantiomeric excess value of asymmetric histidine products can be directly determined from the electrophoretogram of capillary array electrophoresis. The experiment results showed that the optimized asymmetric transformation reaction condition was in the presence of salicylaldehyde as catalyst and acetic acid as solvent.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac051377w