Effects of Oral Prednisone After Stenting in a Rabbit Model of Established Atherosclerosis

• Published in: Journal of the American College of Cardiology 2007-07, Vol.50 (2), p.176-185
• Main Authors: Ribichini, Flavio, MD, Joner, Michael, MD, Ferrero, Valeria, MD, Finn, Aloke V., MD, Crimins, Johanna, BA, Nakazawa, Gaku, MD, Acampado, Eduardo, DVM, Kolodgie, Frank D., PhD, Vassanelli, Corrado, MD, Virmani, Renu, MD
• Format: Article
• Language: English
• Subjects: Administration, Oral; Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Aorta - cytology; Aorta - drug effects; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Atherosclerosis - pathology; Atherosclerosis - therapy; Biological and medical sciences; Blood and lymphatic vessels; Bones, joints and connective tissue. Antiinflammatory agents; Cardiology; Cardiology. Vascular system; Cardiovascular; Cell adhesion & migration; Cell culture; Cell growth; Cell Proliferation - drug effects; Cells, Cultured; Combined Modality Therapy; Cytokines; Disease Models, Animal; Diseases of the cardiovascular system; Euthanasia; Glucocorticoids - therapeutic use; Iliac Artery - pathology; Internal Medicine; Laboratory animals; Medical sciences; Muscular system; Myocytes, Smooth Muscle - drug effects; Pharmacology. Drug treatments; Prednisone - pharmacology; Prednisone - therapeutic use; Rabbits; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Rodents; Smooth muscle; Stents; Thrombosis; Veins & arteries
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.03.031

Effects of Oral Prednisone After Stenting in a Rabbit Model of Established Atherosclerosis Flavio Ribichini, Michael Joner, Valeria Ferrero, Aloke V. Finn, Johanna Crimins, Gaku Nakazawa, Eduardo Acampado, Frank D. Kolodgie, Corrado Vassanelli, Renu Virmani The efficacy of immunosuppressive doses of oral prednisone to inhibit in-stent neointimal proliferation was compared to bare-metal stents (BMS) and to a commercially available paclitaxel-eluting stent (Taxus) in a rabbit model of established atherosclerosis. Compared with control subjects, prednisone- and Taxus-treated animals showed significant reductions in neointimal growth. However, Taxus stents showed significantly more inflammatory cells and fibrin deposition and less endothelialization compared with the other 2 groups. This preclinical model suggests that oral steroid therapy may prevent in-stent restenosis without markedly delaying healing and may be a useful alternative to drug-eluting stents in carefully selected patients.