A DNA prime, orally delivered protein boost vaccination strategy against viral encephalitis

Arboviruses of the families Togaviridae and Flaviviridae are widely distributed and are important causative agents of viral encephalitis, a severe and often fatal disease. The only internationally available vaccine against these diseases is expensive and laborious to manufacture and difficult to adm...

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Bibliographic Details
Published in:Journal of neurovirology 2007-01, Vol.13 (3), p.284-289
Main Authors: Zanin, Mark P, Webster, Diane E, Wesselingh, Steven L
Format: Article
Language:English
Subjects:
Administration, Oral
Alphavirus Infections - immunology
Alphavirus Infections - prevention & control
Animals
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Models, Animal
DNA, Viral - immunology
DNA, Viral - pharmacology
Encephalitis, Viral - immunology
Encephalitis, Viral - prevention & control
Female
Human viral diseases
Immunization, Secondary
Infectious diseases
Injections, Intramuscular
Medical sciences
Mice
Mice, Inbred BALB C
Neurology
Sindbis Virus - genetics
Sindbis Virus - immunology
Vaccines - pharmacology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral diseases of the nervous system
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Description
Summary:Arboviruses of the families Togaviridae and Flaviviridae are widely distributed and are important causative agents of viral encephalitis, a severe and often fatal disease. The only internationally available vaccine against these diseases is expensive and laborious to manufacture and difficult to administer. Therefore, new vaccines are required against these pathogens. This study investigates the use of a DNA-prime, orally delivered protein boost vaccination strategy against viral encephalitis. This vaccination strategy was immunogenic and provided partial protection against viral encephalitis in a murine model, demonstrating the possible applicability of this vaccination strategy for the management of endemic encephalitis.
ISSN:1355-0284
1538-2443
DOI:10.1080/13550280701329646