Family-based association study between GRIK2 polymorphisms and autism spectrum disorders in the Korean trios

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with strong genetic components. The present study comprises the detection of four single nucleotide polymorphisms (SNPs) in GRIK2 followed by a family-based association analysis of the SNPs in 126 Korean ASD trios by using the t...

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Bibliographic Details
Published in:Neuroscience research 2007-07, Vol.58 (3), p.332-335
Main Authors: Kim, Soon Ae, Kim, Jin Hee, Park, Mira, Cho, In Hee, Yoo, Hee Jeong
Format: Article
Language:English
Subjects:
Adolescent
Association
Autism spectrum disorders (ASD)
Autistic Disorder - epidemiology
Autistic Disorder - genetics
Child
Child, Preschool
Family Health
Female
Gene Frequency
Genotype
GluK2 Kainate Receptor
Glutamate receptor 6 ( GRIK2)
Humans
Korea - epidemiology
Linkage Disequilibrium
Male
Polymorphism, Single Nucleotide - genetics
Receptors, Kainic Acid - genetics
Transmission disequilibrium test (TDT)
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Summary:Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with strong genetic components. The present study comprises the detection of four single nucleotide polymorphisms (SNPs) in GRIK2 followed by a family-based association analysis of the SNPs in 126 Korean ASD trios by using the transmission disequilibrium test (TDT) and haplotype analysis. We found preferential transmission of the C allele at the rs3213607 ( P < 0.001) of GRIK2 in ASD and haplotype analysis revealed that one haplotype demonstrated a significant association ( P = 0.023). These results suggest a potential association between GRIK2 and ASD in the Korean population.
ISSN:0168-0102
1872-8111
DOI:10.1016/j.neures.2007.03.002