Antimicrobial activity of Diospyros anisandra

Leaves, root and stem bark of Diospyros anisandra were screened against two strains of Mycobacterium tuberculosis, one resistant and one susceptible to antibiotics, using the microplate Alamar blue assay test. The lypophylic fractions of the root and bark showed significant inhibitory activity again...

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Bibliographic Details
Published in:Fitoterapia 2007-07, Vol.78 (5), p.370-372
Main Authors: Borges-Argáez, Rocio, Canche-Chay, Cristina Isabel, Peña-Rodríguez, Luis M., Said-Fernández, Salvador, Molina-Salinas, Gloria María
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antimicrobial activity
Antimycobacterial activity
Aspergillus niger
Bacillus subtilis
Biological and medical sciences
Candida albicans
Colletotrichum gloeosporioides
Diospyros
Diospyros anisandra
General pharmacology
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Humans
Medical sciences
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Mycobacterium tuberculosis - classification
Mycobacterium tuberculosis - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Bark
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves
Plant Roots
Plumbagin
Staphylococcus aureus
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Summary:Leaves, root and stem bark of Diospyros anisandra were screened against two strains of Mycobacterium tuberculosis, one resistant and one susceptible to antibiotics, using the microplate Alamar blue assay test. The lypophylic fractions of the root and bark showed significant inhibitory activity against both strains, with the hexane fraction of the bark showing the strongest activity (MIC 6.25 μg/ml) against the resistant strain and a significant antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Candida albicans, Aspergillus niger, and Colletotrichum gloeosporioides. The bioassay-guided purification of the bioactive hexane fraction resulted in the isolation and identification of the naphthoquinone plumbagin as one of the metabolites responsible for the biological activity.
ISSN:0367-326X
DOI:10.1016/j.fitote.2007.03.004