Serum lipid and lipoprotein alterations represent recovery of liver function after hepatectomy

: Background: The assessment of liver function during human liver regeneration is necessary to prevent unexpected liver failure and to prepare for further treatment. We selected patients prospectively and measured serum lipid and lipoprotein levels to identify which lipids and lipoproteins could rep...

Full description

Saved in:
Bibliographic Details
Published in:Liver international 2006-03, Vol.26 (2), p.203-210
Main Authors: Kawamoto, Masaki, Mizuguchi, Toru, Nagayama, Minoru, Nobuoka, Takayuki, Kawasaki, Hiroyuki, Sato, Taishi, Koito, Kazumitsu, Parker, Susan, Katsuramaki, Tadashi, Hirata, Koichi
Format: Article
Language:English
Subjects:
Aged
apolipoprotein B
Apolipoproteins B - blood
Hepatectomy
Humans
hyaluronate
Hyaluronic Acid - blood
LDL
Lipoproteins, LDL - blood
Liver Function Tests
liver regeneration
Liver Regeneration - physiology
Middle Aged
Recovery of Function - physiology
β-lipoprotein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:: Background: The assessment of liver function during human liver regeneration is necessary to prevent unexpected liver failure and to prepare for further treatment. We selected patients prospectively and measured serum lipid and lipoprotein levels to identify which lipids and lipoproteins could represent recovery of liver function in human liver regeneration. Methods: Thirty selected patients who underwent hepatectomy were divided into three groups depending on the serum hyaluronate (HA) level and the type of liver resection. Results: We found three patterns of lipid and lipoprotein alterations after hepatectomy. Among the lipids and lipoproteins examined, the serum β‐lipoprotein and low‐density lipoprotein (LDL) levels were significantly different among the groups at 7 days after hepatectomy. The alteration of the apolipoprotein (Apo) B level was similar to that of LDL. The LDL level was correlated with both β‐lipoprotein and Apo B before hepatectomy (r=0.653 and 0.894, respectively) and at 7 days after hepatectomy (r=0.841 and 0.943, respectively). Conclusion: Serum HA before hepatectomy can reflect postoperative liver function depending on the type of liver resection. Recovery of the β‐lipoprotein and LDL levels can reflect the recovery of liver function in human liver regeneration within the early period in association with the Apo B level.
ISSN:1478-3223
1478-3231
DOI:10.1111/j.1478-3231.2005.01217.x