Direct Aqueous Injection Liquid Chromatography/Electrospray Ionization-Mass Spectrometry/Mass Spectrometry Analysis of Water for Atrazine, Simazine, and Their Chlorotriazine Metabolites

A method is reported for the determination of atrazine, simazine, and their respective dealkylated chlorotriazine metabolites in ground, surface, and finished drinking water. Water samples are diluted 1:4 in an injection vial prior to analysis using liquid chromatography/electrospray ionization-mass...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2006-02, Vol.54 (3), p.713-719
Main Authors: Huang, Sung-Ben, Mayer, Thomas J, Yokley, Robert A, Perez, Rolando
Format: Article
Language:English
Subjects:
atrazine
Atrazine - analysis
Atrazine - metabolism
Chromatography, Liquid - methods
dealkylated chlorotriazine metaboites
direct aqueous injection
drinking water
electrospray ionization
groundwater contamination
herbicide residues
injection
ionization
liquid chromatography
mass spectrometry
Mass Spectrometry - methods
metabolites
organochlorine compounds
Reproducibility of Results
simazine
Simazine - analysis
Simazine - metabolism
Spectrometry, Mass, Electrospray Ionization
surface water
triazines
Triazines - metabolism
Water - analysis
water pollution
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Summary:A method is reported for the determination of atrazine, simazine, and their respective dealkylated chlorotriazine metabolites in ground, surface, and finished drinking water. Water samples are diluted 1:4 in an injection vial prior to analysis using liquid chromatography/electrospray ionization-mass spectrometry/mass spectrometry (LC/ESI-MS/MS). The lower limit of method validation is 0.10 μg/L (ppb) for 2-chloro-4-(ethylamino)-6-isopropylamino)-s-triazine (atrazine, G-30027), 2-chloro-4, 6-(diethylamino)-s-triazine (simazine, G-27692), 2-amino-4-chloro-6-(isopropylamino)-s-triazine (deethylatrazine, DEA, or G-30033), 2-amino-4-chloro-6-(ethylamino)-s-triazine (deisopropylatrazine, DIA, or G-28279), and 2,4-diamino-6-chloro-s-triazine (didealkylatrazine, DDA, or G-28273). The overall mean procedural recoveries (and % relative standard deviations) for atrazine, simazine, DEA, DIA, and DDA are 98 (4.4), 102 (3.6), 99 (4.8), 103 (4.0), and 109% (4.8%), respectively, in finished drinking water; 108 (2.7), 104 (5.4), 113 (4.5), 111 (5.2), and 105% (5.3%), respectively, in groundwater; and 96 (6.9), 103 (4.2), 102 (4.4), 102 (5.2), and 102% (8.2%), respectively, in surface water. The method validation was conducted under U.S. EPA FIFRA Good Laboratory Practice Guidelines 40 CFR 160. Keywords: Direct aqueous injection; atrazine; simazine; dealkylated chlorotriazine metabolites; good laboratory practices (GLP); mass spectrometry/mass spectrometry
ISSN:0021-8561
1520-5118
DOI:10.1021/jf052968q