Monoamine receptors in human corneal epithelium and endothelium

. Purpose:  Monoamine receptors are found throughout the body. Reports about the presence of monoamine receptors in the human cornea are inconsistent. Methods:  Immunohistochemistry, immunofluorescence and immunoblotting were used to localize monoamine receptor sites on human corneal epithelium and...

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Bibliographic Details
Published in:Acta ophthalmologica Scandinavica 2006-02, Vol.84 (1), p.110-115
Main Authors: Grueb, Matthias, Wallenfels‐Thilo, Barbara, Denk, Oliver, Mielke, Joerg, Reinthal, Eva, Rohrbach, Jens Martin, Bartz‐Schmidt, Karl Ulrich
Format: Article
Language:English
Subjects:
Adult
Aged
Blotting, Western
cornea
endothelium
Endothelium, Corneal - metabolism
epithelium
Epithelium, Corneal - metabolism
Female
Fluorescent Antibody Technique, Indirect
Humans
Immunoblotting
Immunohistochemistry
Male
Middle Aged
monoamine‐receptor
Receptors, Adrenergic - metabolism
Receptors, Dopamine - metabolism
Receptors, Serotonin - metabolism
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Summary:. Purpose:  Monoamine receptors are found throughout the body. Reports about the presence of monoamine receptors in the human cornea are inconsistent. Methods:  Immunohistochemistry, immunofluorescence and immunoblotting were used to localize monoamine receptor sites on human corneal epithelium and endothelium. Results:  Antibodies to alpha‐1, beta‐1 and beta‐2 adrenergic receptors and to D1‐like and 5HT‐7 receptors were bound in corneal epithelium. Antibodies to alpha‐1, alpha‐2A, beta‐1 and beta‐2 adrenergic receptors and to 5HT‐7 receptors were bound in corneal endothelium. Conclusions:  Our data demonstrate the presence of several monoamine receptors in the human cornea. These receptors may play a role in the regulation of fluid transport or corneal homeostasis.
ISSN:1395-3907
1600-0420
DOI:10.1111/j.1600-0420.2005.00551.x