Morphometric and microscopic evaluation of the effect of a solution of alendronate as an intracanal therapeutic agent in rat teeth submitted to late reimplantation

–  The use of substances that inhibit root resorption may be an alternative for cases of unsuccessful reimplants. Hence, the purpose of this study was to test a solution of alendronate, a resorption inhibitor, as an intracanal therapeutic agent for teeth submitted to late reimplantation. Thirty rat...

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Published in:Dental traumatology 2007-08, Vol.23 (4), p.218-221
Main Authors: Mori, Graziela Garrido, Garcia, Roberto Brandão, De Moraes, Ivaldo Gomes, Bramante, Clóvis Monteiro, Bernardineli, Norberti
Format: Article
Language:English
Subjects:
alendroante
Alendronate - therapeutic use
Animals
Bone Density Conservation Agents - therapeutic use
Calcium Hydroxide - therapeutic use
Dentistry
Male
Rats
Rats, Wistar
reimplanted teeth
resorption
Root Canal Irrigants - therapeutic use
Root Resorption - prevention & control
Statistics, Nonparametric
Tooth Avulsion - therapy
Tooth Replantation
Treatment Outcome
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Summary:–  The use of substances that inhibit root resorption may be an alternative for cases of unsuccessful reimplants. Hence, the purpose of this study was to test a solution of alendronate, a resorption inhibitor, as an intracanal therapeutic agent for teeth submitted to late reimplantation. Thirty rat maxillary right central incisors were avulsed and kept dry for 30 min. The teeth were instrumented, and the root surfaces treated with 1% hypochlorite solution followed by application of 2% sodium fluoride. Thereafter, the teeth were divided in two groups according to the intracanal dressing: (i) group I, solution of alendronate and (ii) group II, calcium hydroxide paste. Teeth were then reimplanted in their respective sockets. The animals were killed at 15, 30 and 60 days after reimplantation and the samples processed for morphometric and microscopic analysis. The results demonstrated that the solution of alendronate and the calcium hydroxide paste limited the root resorption, yet did not impair its occurrence. It may be concluded that alendronate and calcium hydroxide paste demonstrated similar behavior.
ISSN:1600-4469
1600-9657
DOI:10.1111/j.1600-9657.2006.00437.x