The potential of mesothelial cells in tissue engineering and regenerative medicine applications

Injury to the serosa through injurious agents such as radiation, surgery, infection and disease results in the loss of the protective surface mesothelium and often leads to fibrous adhesion formation. Mechanisms that increase the rate of mesothialisation are therefore actively being investigated in...

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Bibliographic Details
Published in:International journal of artificial organs 2007-06, Vol.30 (6), p.527-540
Main Authors: Herrick, S E, Mutsaers, S E
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion
Epithelial Cells - cytology
Epithelial Cells - physiology
Epithelium - embryology
Epithelium - physiology
Humans
Omentum - cytology
Peritoneum - cytology
Regeneration - physiology
Regenerative Medicine - trends
Serous Membrane - injuries
Stem Cell Transplantation
Stem Cells - physiology
Tissue Adhesions - prevention & control
Tissue Engineering - trends
Wound Healing - physiology
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Summary:Injury to the serosa through injurious agents such as radiation, surgery, infection and disease results in the loss of the protective surface mesothelium and often leads to fibrous adhesion formation. Mechanisms that increase the rate of mesothialisation are therefore actively being investigated in order to reduce the formation of adhesions. These include intraperitoneal delivery of cultured mesothelial cells as well as administration of factors that are known to increase mesothelial proliferation and migration. An exciting alternative that has only recently received attention, is the possible role of mesothelial progenitor cells in the repair and regeneration of denuded serosal areas. Accumulating evidence suggests that such a population exists and under certain conditions is able to form a number of defined cell types indicating a degree of plasticity. Such properties may explain the extensive use of mesothelial cells in various tissue engineering applications including the development of vascular conduits and peripheral nerve replacements. It is likely that with the rapid explosion in the fields of tissue engineering and regenerative medicine, a greater understanding of the potential of mesothelial progenitor cells to repair, replace and possibly regenerate damaged or defective tissue will be uncovered.
ISSN:0391-3988
1724-6040
DOI:10.1177/039139880703000611