First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes

Three single-filament isolates of Aphanizomenon flos-aquae from two German lakes were found to produce remarkable amounts of the cyanobacterial hepatotoxin cylindrospermopsin (CYN). CYN-synthesis of the strains were evidenced both by LC-MS/MS analysis and detection of PCR products of gene fragments...

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Bibliographic Details
Published in:Toxicon (Oxford) 2006-02, Vol.47 (2), p.156-162
Main Authors: Preußel, Karina, Stüken, Anke, Wiedner, Claudia, Chorus, Ingrid, Fastner, Jutta
Format: Article
Language:English
Subjects:
Aphanizomenon - isolation & purification
Aphanizomenon - metabolism
Aphanizomenon flos-aquae
Bacterial Toxins
Bacteriology
Biological and medical sciences
Cyanobacteria
Cylindrospermopsin
Fresh Water - microbiology
Fundamental and applied biological sciences. Psychology
Germany
Microbiology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Uracil - analogs & derivatives
Uracil - biosynthesis
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Summary:Three single-filament isolates of Aphanizomenon flos-aquae from two German lakes were found to produce remarkable amounts of the cyanobacterial hepatotoxin cylindrospermopsin (CYN). CYN-synthesis of the strains were evidenced both by LC-MS/MS analysis and detection of PCR products of gene fragments which are implicated in the biosynthesis of the toxin. The strains contain CYN in the range of 2.3–6.6 mg g −1 of cellular dry weight. To our knowledge this is the first report of CYN in A. flos-aquae.
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2005.10.013