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First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes
Three single-filament isolates of Aphanizomenon flos-aquae from two German lakes were found to produce remarkable amounts of the cyanobacterial hepatotoxin cylindrospermopsin (CYN). CYN-synthesis of the strains were evidenced both by LC-MS/MS analysis and detection of PCR products of gene fragments...
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| Published in: | Toxicon (Oxford) 2006-02, Vol.47 (2), p.156-162 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c393t-173bb338fe8d88956620b7be24258843a362ea89c01c9644a6124ce3268addcd3 |
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| cites | cdi_FETCH-LOGICAL-c393t-173bb338fe8d88956620b7be24258843a362ea89c01c9644a6124ce3268addcd3 |
| container_end_page | 162 |
| container_issue | 2 |
| container_start_page | 156 |
| container_title | Toxicon (Oxford) |
| container_volume | 47 |
| creator | Preußel, Karina Stüken, Anke Wiedner, Claudia Chorus, Ingrid Fastner, Jutta |
| description | Three single-filament isolates of
Aphanizomenon flos-aquae from two German lakes were found to produce remarkable amounts of the cyanobacterial hepatotoxin cylindrospermopsin (CYN). CYN-synthesis of the strains were evidenced both by LC-MS/MS analysis and detection of PCR products of gene fragments which are implicated in the biosynthesis of the toxin. The strains contain CYN in the range of 2.3–6.6
mg
g
−1 of cellular dry weight. To our knowledge this is the first report of CYN in
A. flos-aquae. |
| doi_str_mv | 10.1016/j.toxicon.2005.10.013 |
| format | article |
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Aphanizomenon flos-aquae from two German lakes were found to produce remarkable amounts of the cyanobacterial hepatotoxin cylindrospermopsin (CYN). CYN-synthesis of the strains were evidenced both by LC-MS/MS analysis and detection of PCR products of gene fragments which are implicated in the biosynthesis of the toxin. The strains contain CYN in the range of 2.3–6.6
mg
g
−1 of cellular dry weight. To our knowledge this is the first report of CYN in
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Aphanizomenon flos-aquae from two German lakes were found to produce remarkable amounts of the cyanobacterial hepatotoxin cylindrospermopsin (CYN). CYN-synthesis of the strains were evidenced both by LC-MS/MS analysis and detection of PCR products of gene fragments which are implicated in the biosynthesis of the toxin. The strains contain CYN in the range of 2.3–6.6
mg
g
−1 of cellular dry weight. To our knowledge this is the first report of CYN in
A. flos-aquae.</description><subject>Aphanizomenon - isolation & purification</subject><subject>Aphanizomenon - metabolism</subject><subject>Aphanizomenon flos-aquae</subject><subject>Bacterial Toxins</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Cyanobacteria</subject><subject>Cylindrospermopsin</subject><subject>Fresh Water - microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Germany</subject><subject>Microbiology</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Uracil - analogs & derivatives</subject><subject>Uracil - biosynthesis</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkEtv1DAURi0EotPCTwB5QwWLDH4kjrNC1YgWpEpsytpy7BvwkNip7ZROfz0eTaQuWV3p6nz3cRB6R8mWEio-77c5PDoT_JYR0pTellD-Am2obLuK04a8RBtCalqRgp-h85T2hBAuO_EanVHBG9EwtkH52sWUcYQ5xIyDx-YwOm9jSDPEKczJeTzHYBfj_C98Nf_W3j2FCXxBhzGkSt8vGvDH3UH70GuTITr9CbsURp3B4iGGCee_Ad-UcdrjUf-B9Aa9GvSY4O1aL9DP6693u2_V7Y-b77ur28rwjueKtrzvOZcDSCtl1wjBSN_2wGrWSFlzzQUDLTtDqOlEXWtBWW2AMyG1tcbyC3R5mls-uF8gZTW5ZGActYewJNWSlnWMiQI2J9CUx1OEQc3RTToeFCXqqFvt1apbHXUf20V3yb1fFyz9BPY5tfotwIcV0MnocYjaG5eeubbumqauC_flxEHR8eAgqmQceAPWRTBZ2eD-c8o_il-iqQ</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Preußel, Karina</creator><creator>Stüken, Anke</creator><creator>Wiedner, Claudia</creator><creator>Chorus, Ingrid</creator><creator>Fastner, Jutta</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes</title><author>Preußel, Karina ; Stüken, Anke ; Wiedner, Claudia ; Chorus, Ingrid ; Fastner, Jutta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-173bb338fe8d88956620b7be24258843a362ea89c01c9644a6124ce3268addcd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aphanizomenon - isolation & purification</topic><topic>Aphanizomenon - metabolism</topic><topic>Aphanizomenon flos-aquae</topic><topic>Bacterial Toxins</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Cyanobacteria</topic><topic>Cylindrospermopsin</topic><topic>Fresh Water - microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Germany</topic><topic>Microbiology</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Uracil - analogs & derivatives</topic><topic>Uracil - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Preußel, Karina</creatorcontrib><creatorcontrib>Stüken, Anke</creatorcontrib><creatorcontrib>Wiedner, Claudia</creatorcontrib><creatorcontrib>Chorus, Ingrid</creatorcontrib><creatorcontrib>Fastner, Jutta</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Preußel, Karina</au><au>Stüken, Anke</au><au>Wiedner, Claudia</au><au>Chorus, Ingrid</au><au>Fastner, Jutta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>47</volume><issue>2</issue><spage>156</spage><epage>162</epage><pages>156-162</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>Three single-filament isolates of
Aphanizomenon flos-aquae from two German lakes were found to produce remarkable amounts of the cyanobacterial hepatotoxin cylindrospermopsin (CYN). CYN-synthesis of the strains were evidenced both by LC-MS/MS analysis and detection of PCR products of gene fragments which are implicated in the biosynthesis of the toxin. The strains contain CYN in the range of 2.3–6.6
mg
g
−1 of cellular dry weight. To our knowledge this is the first report of CYN in
A. flos-aquae.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16356522</pmid><doi>10.1016/j.toxicon.2005.10.013</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Toxicon (Oxford), 2006-02, Vol.47 (2), p.156-162 |
| issn | 0041-0101 1879-3150 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Aphanizomenon - isolation & purification Aphanizomenon - metabolism Aphanizomenon flos-aquae Bacterial Toxins Bacteriology Biological and medical sciences Cyanobacteria Cylindrospermopsin Fresh Water - microbiology Fundamental and applied biological sciences. Psychology Germany Microbiology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Uracil - analogs & derivatives Uracil - biosynthesis |
| title | First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes |
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