Chronic ACE inhibitor treatment increases angiotensin type 1 receptor binding in vivo in the dog kidney

• Published in: European journal of nuclear medicine and molecular imaging 2008-06, Vol.35 (6), p.1109-1116
• Main Authors: Zober, Tamas G., Fabucci, Maria Elena, Zheng, Wei, Brown, Phillip R., Seckin, Esen, Mathews, William B., Sandberg, Kathryn, Szabo, Zsolt
• Format: Article
• Language: English
• Subjects: Angiotensin-Converting Enzyme Inhibitors - administration & dosage; Animals; Binding sites; Cardiology; Dogs; Dose-Response Relationship, Drug; Enzymes; Imaging; Inhibitor drugs; Kidney - diagnostic imaging; Kidney - drug effects; Kidney - metabolism; Kidneys; Male; Medicine; Medicine & Public Health; Nuclear Medicine; Oncology; Original Article; Orthopedics; Protein Binding - drug effects; Radiology; Radionuclide Imaging; Receptor, Angiotensin, Type 1 - metabolism; Tomography
• ISSN: 1619-7070; 1619-7089
• DOI: 10.1007/s00259-007-0667-z

Purpose PET imaging has been recently introduced for investigating the type 1 angiotensin II receptor (AT 1 R) in vivo . The goal of the present study was to investigate the effects of acute and chronic exposure to angiotensin converting enzyme inhibitors (ACEI) on the AT 1 R in the dog kidney. Methods Animals were imaged at baseline, after acute intravenous ACEI treatment and after a chronic 2-week exposure to an oral ACEI. Control animals were imaged at identical time points in the absence of ACEI treatment. Results In vivo AT 1 R binding expressed by K i was increased in the renal cortex by chronic ACEI treatment ( p