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Chronic ACE inhibitor treatment increases angiotensin type 1 receptor binding in vivo in the dog kidney
Purpose PET imaging has been recently introduced for investigating the type 1 angiotensin II receptor (AT 1 R) in vivo . The goal of the present study was to investigate the effects of acute and chronic exposure to angiotensin converting enzyme inhibitors (ACEI) on the AT 1 R in the dog kidney. Meth...
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| Published in: | European journal of nuclear medicine and molecular imaging 2008-06, Vol.35 (6), p.1109-1116 |
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| Main Authors: | , , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c400t-a1c02fa1f469d304648c432668321610d19bb9fe4c466d5d0ddecc70910881833 |
| container_end_page | 1116 |
| container_issue | 6 |
| container_start_page | 1109 |
| container_title | European journal of nuclear medicine and molecular imaging |
| container_volume | 35 |
| creator | Zober, Tamas G. Fabucci, Maria Elena Zheng, Wei Brown, Phillip R. Seckin, Esen Mathews, William B. Sandberg, Kathryn Szabo, Zsolt |
| description | Purpose
PET imaging has been recently introduced for investigating the type 1 angiotensin II receptor (AT
1
R) in vivo
.
The goal of the present study was to investigate the effects of acute and chronic exposure to angiotensin converting enzyme inhibitors (ACEI) on the AT
1
R in the dog kidney.
Methods
Animals were imaged at baseline, after acute intravenous ACEI treatment and after a chronic 2-week exposure to an oral ACEI. Control animals were imaged at identical time points in the absence of ACEI treatment.
Results
In vivo AT
1
R binding expressed by
K
i
was increased in the renal cortex by chronic ACEI treatment (
p
|
| doi_str_mv | 10.1007/s00259-007-0667-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70729267</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70729267</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-a1c02fa1f469d304648c432668321610d19bb9fe4c466d5d0ddecc70910881833</originalsourceid><addsrcrecordid>eNqFkUFr3DAQhUVpaNK0P6CXInroze2MbMvWMSxJUwj00pyFLY29SnelraQNbH59ZXZJoFB6mofmmxmeHmMfEL4gQPc1AYhWVUVWIGVXPb1iFyhRVR306vWz7uCcvU3pAQB70as37Bx77EEJuGDzah2Dd4Zfra6582s3uhwiz5GGvCWfy5spOlHig59dyOST8zwfdsSRRzK0W_jReev8XGj-6B7DUvOauA0z_-Wsp8M7djYNm0TvT_WS3d9c_1zdVnc_vn1fXd1VpgHI1YAGxDTg1Ehla2hk05umFlL2tShuwKIaRzVRYxopbWvBWjKmA4XQF091fck-H_fuYvi9p5T11iVDm83gKeyTLr8hlJDdf0FUnRIoVAE__QU-hH30xYQW2Mi2bcVyFo-QiSGlSJPeRbcd4kEj6CUrfcxKL3LJSj-VmY-nxftxS_Zl4hROAcQRSKXlZ4ovl_-99Q-KfZ6D</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214655523</pqid></control><display><type>article</type><title>Chronic ACE inhibitor treatment increases angiotensin type 1 receptor binding in vivo in the dog kidney</title><source>Springer Nature</source><creator>Zober, Tamas G. ; Fabucci, Maria Elena ; Zheng, Wei ; Brown, Phillip R. ; Seckin, Esen ; Mathews, William B. ; Sandberg, Kathryn ; Szabo, Zsolt</creator><creatorcontrib>Zober, Tamas G. ; Fabucci, Maria Elena ; Zheng, Wei ; Brown, Phillip R. ; Seckin, Esen ; Mathews, William B. ; Sandberg, Kathryn ; Szabo, Zsolt</creatorcontrib><description>Purpose
PET imaging has been recently introduced for investigating the type 1 angiotensin II receptor (AT
1
R) in vivo
.
The goal of the present study was to investigate the effects of acute and chronic exposure to angiotensin converting enzyme inhibitors (ACEI) on the AT
1
R in the dog kidney.
Methods
Animals were imaged at baseline, after acute intravenous ACEI treatment and after a chronic 2-week exposure to an oral ACEI. Control animals were imaged at identical time points in the absence of ACEI treatment.
Results
In vivo AT
1
R binding expressed by
K
i
was increased in the renal cortex by chronic ACEI treatment (
p
< 0.05). In vitro measurements of AT
1
R density (
B
max
) also revealed significant increases in AT
1
R in isolated glomeruli (
p
< 0.05). Plasma renin activity was increased, but angiotensin II (Ang II) and the Ang II/Ang I ratio showed a weak correlation with chronic ACEI treatment, consistent with an Ang II escape phenomenon.
Conclusion
This study reveals, for the first time, that chronic ACEI treatment increases AT
1
R binding in vivo in the dog renal cortex.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-007-0667-z</identifier><identifier>PMID: 18180920</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Angiotensin-Converting Enzyme Inhibitors - administration & dosage ; Animals ; Binding sites ; Cardiology ; Dogs ; Dose-Response Relationship, Drug ; Enzymes ; Imaging ; Inhibitor drugs ; Kidney - diagnostic imaging ; Kidney - drug effects ; Kidney - metabolism ; Kidneys ; Male ; Medicine ; Medicine & Public Health ; Nuclear Medicine ; Oncology ; Original Article ; Orthopedics ; Protein Binding - drug effects ; Radiology ; Radionuclide Imaging ; Receptor, Angiotensin, Type 1 - metabolism ; Tomography</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2008-06, Vol.35 (6), p.1109-1116</ispartof><rights>Springer-Verlag 2007</rights><rights>Springer-Verlag 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-a1c02fa1f469d304648c432668321610d19bb9fe4c466d5d0ddecc70910881833</citedby><cites>FETCH-LOGICAL-c400t-a1c02fa1f469d304648c432668321610d19bb9fe4c466d5d0ddecc70910881833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18180920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zober, Tamas G.</creatorcontrib><creatorcontrib>Fabucci, Maria Elena</creatorcontrib><creatorcontrib>Zheng, Wei</creatorcontrib><creatorcontrib>Brown, Phillip R.</creatorcontrib><creatorcontrib>Seckin, Esen</creatorcontrib><creatorcontrib>Mathews, William B.</creatorcontrib><creatorcontrib>Sandberg, Kathryn</creatorcontrib><creatorcontrib>Szabo, Zsolt</creatorcontrib><title>Chronic ACE inhibitor treatment increases angiotensin type 1 receptor binding in vivo in the dog kidney</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
PET imaging has been recently introduced for investigating the type 1 angiotensin II receptor (AT
1
R) in vivo
.
The goal of the present study was to investigate the effects of acute and chronic exposure to angiotensin converting enzyme inhibitors (ACEI) on the AT
1
R in the dog kidney.
Methods
Animals were imaged at baseline, after acute intravenous ACEI treatment and after a chronic 2-week exposure to an oral ACEI. Control animals were imaged at identical time points in the absence of ACEI treatment.
Results
In vivo AT
1
R binding expressed by
K
i
was increased in the renal cortex by chronic ACEI treatment (
p
< 0.05). In vitro measurements of AT
1
R density (
B
max
) also revealed significant increases in AT
1
R in isolated glomeruli (
p
< 0.05). Plasma renin activity was increased, but angiotensin II (Ang II) and the Ang II/Ang I ratio showed a weak correlation with chronic ACEI treatment, consistent with an Ang II escape phenomenon.
Conclusion
This study reveals, for the first time, that chronic ACEI treatment increases AT
1
R binding in vivo in the dog renal cortex.</description><subject>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</subject><subject>Animals</subject><subject>Binding sites</subject><subject>Cardiology</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enzymes</subject><subject>Imaging</subject><subject>Inhibitor drugs</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Protein Binding - drug effects</subject><subject>Radiology</subject><subject>Radionuclide Imaging</subject><subject>Receptor, Angiotensin, Type 1 - metabolism</subject><subject>Tomography</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkUFr3DAQhUVpaNK0P6CXInroze2MbMvWMSxJUwj00pyFLY29SnelraQNbH59ZXZJoFB6mofmmxmeHmMfEL4gQPc1AYhWVUVWIGVXPb1iFyhRVR306vWz7uCcvU3pAQB70as37Bx77EEJuGDzah2Dd4Zfra6582s3uhwiz5GGvCWfy5spOlHig59dyOST8zwfdsSRRzK0W_jReev8XGj-6B7DUvOauA0z_-Wsp8M7djYNm0TvT_WS3d9c_1zdVnc_vn1fXd1VpgHI1YAGxDTg1Ehla2hk05umFlL2tShuwKIaRzVRYxopbWvBWjKmA4XQF091fck-H_fuYvi9p5T11iVDm83gKeyTLr8hlJDdf0FUnRIoVAE__QU-hH30xYQW2Mi2bcVyFo-QiSGlSJPeRbcd4kEj6CUrfcxKL3LJSj-VmY-nxftxS_Zl4hROAcQRSKXlZ4ovl_-99Q-KfZ6D</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Zober, Tamas G.</creator><creator>Fabucci, Maria Elena</creator><creator>Zheng, Wei</creator><creator>Brown, Phillip R.</creator><creator>Seckin, Esen</creator><creator>Mathews, William B.</creator><creator>Sandberg, Kathryn</creator><creator>Szabo, Zsolt</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Chronic ACE inhibitor treatment increases angiotensin type 1 receptor binding in vivo in the dog kidney</title><author>Zober, Tamas G. ; Fabucci, Maria Elena ; Zheng, Wei ; Brown, Phillip R. ; Seckin, Esen ; Mathews, William B. ; Sandberg, Kathryn ; Szabo, Zsolt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-a1c02fa1f469d304648c432668321610d19bb9fe4c466d5d0ddecc70910881833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</topic><topic>Animals</topic><topic>Binding sites</topic><topic>Cardiology</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enzymes</topic><topic>Imaging</topic><topic>Inhibitor drugs</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Protein Binding - drug effects</topic><topic>Radiology</topic><topic>Radionuclide Imaging</topic><topic>Receptor, Angiotensin, Type 1 - metabolism</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zober, Tamas G.</creatorcontrib><creatorcontrib>Fabucci, Maria Elena</creatorcontrib><creatorcontrib>Zheng, Wei</creatorcontrib><creatorcontrib>Brown, Phillip R.</creatorcontrib><creatorcontrib>Seckin, Esen</creatorcontrib><creatorcontrib>Mathews, William B.</creatorcontrib><creatorcontrib>Sandberg, Kathryn</creatorcontrib><creatorcontrib>Szabo, Zsolt</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zober, Tamas G.</au><au>Fabucci, Maria Elena</au><au>Zheng, Wei</au><au>Brown, Phillip R.</au><au>Seckin, Esen</au><au>Mathews, William B.</au><au>Sandberg, Kathryn</au><au>Szabo, Zsolt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic ACE inhibitor treatment increases angiotensin type 1 receptor binding in vivo in the dog kidney</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>35</volume><issue>6</issue><spage>1109</spage><epage>1116</epage><pages>1109-1116</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
PET imaging has been recently introduced for investigating the type 1 angiotensin II receptor (AT
1
R) in vivo
.
The goal of the present study was to investigate the effects of acute and chronic exposure to angiotensin converting enzyme inhibitors (ACEI) on the AT
1
R in the dog kidney.
Methods
Animals were imaged at baseline, after acute intravenous ACEI treatment and after a chronic 2-week exposure to an oral ACEI. Control animals were imaged at identical time points in the absence of ACEI treatment.
Results
In vivo AT
1
R binding expressed by
K
i
was increased in the renal cortex by chronic ACEI treatment (
p
< 0.05). In vitro measurements of AT
1
R density (
B
max
) also revealed significant increases in AT
1
R in isolated glomeruli (
p
< 0.05). Plasma renin activity was increased, but angiotensin II (Ang II) and the Ang II/Ang I ratio showed a weak correlation with chronic ACEI treatment, consistent with an Ang II escape phenomenon.
Conclusion
This study reveals, for the first time, that chronic ACEI treatment increases AT
1
R binding in vivo in the dog renal cortex.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18180920</pmid><doi>10.1007/s00259-007-0667-z</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1619-7070 |
| ispartof | European journal of nuclear medicine and molecular imaging, 2008-06, Vol.35 (6), p.1109-1116 |
| issn | 1619-7070 1619-7089 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70729267 |
| source | Springer Nature |
| subjects | Angiotensin-Converting Enzyme Inhibitors - administration & dosage Animals Binding sites Cardiology Dogs Dose-Response Relationship, Drug Enzymes Imaging Inhibitor drugs Kidney - diagnostic imaging Kidney - drug effects Kidney - metabolism Kidneys Male Medicine Medicine & Public Health Nuclear Medicine Oncology Original Article Orthopedics Protein Binding - drug effects Radiology Radionuclide Imaging Receptor, Angiotensin, Type 1 - metabolism Tomography |
| title | Chronic ACE inhibitor treatment increases angiotensin type 1 receptor binding in vivo in the dog kidney |
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