Enhanced food intake regulatory responses after a glucose drink in hyperinsulinemic men

Objective: To determine the effect of hyperinsulinemia on food intake and plasma concentrations of glucose and food intake regulatory hormones in men after a glucose drink. Design: Cross-sectional clinical intervention study of the effect of a glucose drink on food intake regulation. Subjects: Thirt...

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Bibliographic Details
Published in:International Journal of Obesity 2007-08, Vol.31 (8), p.1222-1231
Main Authors: Samra, R.A, Wolever, T.M.S, Anderson, G.H
Format: Article
Language:English
Subjects:
Adiponectin - blood
Administration, Oral
Adolescent
Adult
Aged
Appetite
Appetite Regulation - drug effects
Appetite Regulation - physiology
Biological and medical sciences
Blood
blood glucose
Blood Glucose - metabolism
Body mass index
carbohydrate intake
Carbohydrates
Causes of
Cholecystokinin - blood
Complications and side effects
Cross-Sectional Studies
Diabetes
epidemiological studies
Epidemiology
Expenditures
Feeding. Feeding behavior
Food
food intake
Fundamental and applied biological sciences. Psychology
Ghrelin - blood
Glucose
Glucose - administration & dosage
Glucose - pharmacology
Health Promotion and Disease Prevention
hormonal regulation
Hormones
Humans
hyperinsulinemia
Hyperinsulinism - metabolism
Hyperinsulinism - physiopathology
Insulin
Insulin - blood
Insulin resistance
insulin secretion
Internal Medicine
Leptin - blood
Male
Medical sciences
Medicine
Medicine & Public Health
men
Metabolic Diseases
Middle Aged
Obesity
original-article
peptide hormones
Physiology
Pizza
Plasma
protective effect
Public Health
Risk factors
satiety
Vertebrates: anatomy and physiology, studies on body, several organs or systems
weight gain
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Summary:Objective: To determine the effect of hyperinsulinemia on food intake and plasma concentrations of glucose and food intake regulatory hormones in men after a glucose drink. Design: Cross-sectional clinical intervention study of the effect of a glucose drink on food intake regulation. Subjects: Thirty-three normoinsulinemic (NI) (body mass index (BMI) = 25.3 +/- 0.6; age = 41.4 +/- 2.4) and 32 hyperinsulinemic (HI) men (BMI = 29.5 +/- 0.6; age = 43.4 +/- 2.6). Measurements: Food intake was measured from a pizza meal 1 h after subjects consumed either a noncaloric sweetened drink or a glucose-containing drink (75g/300 ml) in random order on two occasions. On another occasion, blood samples were taken every 30 min for 2 h after the glucose drink. Results: Fasting insulin in the HI and NI men was 65 +/- 3 (mean +/- s.e.m.) and 26 +/- 1.5 pmol/l, respectively. Food intake at the pizza meal was reduced by the glucose drink (P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0803565