Root resorption associated with orthodontic force in inbred mice: genetic contributions

Root resorption (RR) is an unwanted sequela of orthodontic treatment. Despite rigorous investigation, no single factor or group of factors that directly causes RR has been identified. The purpose of this study was to examine the effect of the genotype on susceptibility or resistance to develop RR se...

Full description

Saved in:
Bibliographic Details
Published in:European journal of orthodontics 2006-02, Vol.28 (1), p.13-19
Main Authors: Al-Qawasmi, Riyad A., Hartsfield, James K., Everett, Eric T., Weaver, Marjorie R., Foroud, Tatiana M., Faust, Deidra M., Roberts, W. Eugene
Format: Article
Language:English
Subjects:
Acid Phosphatase - metabolism
Animals
Biomarkers - metabolism
Dental Stress Analysis
Dentistry
Disease Models, Animal
Genetic Predisposition to Disease - genetics
Genotype
Isoenzymes - metabolism
Male
Mice
Mice, Inbred Strains
Random Allocation
Reproducibility of Results
Root Resorption - etiology
Root Resorption - genetics
Tartrate-Resistant Acid Phosphatase
Tooth Movement Techniques - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Root resorption (RR) is an unwanted sequela of orthodontic treatment. Despite rigorous investigation, no single factor or group of factors that directly causes RR has been identified. The purpose of this study was to examine the effect of the genotype on susceptibility or resistance to develop RR secondary to orthodontic force. Nine-week-old male mice from eight inbred strains were used and randomly distributed into control (C) or treatment (T) groups as follows: A/J (C = 9,T = 9), C57BL/6J (C = 7,T = 8), C3H/HeJ (C = 8,T = 6), BALB/cJ (C = 8,T = 6), 129P3/J (C = 6,T = 8), DBA/2J (C = 8,T = 9), SJL/J (C = 8,T = 10), and AKR/J (C = 9,T = 8). Each of the treated mice received an orthodontic appliance to tip the maxillary left first molar mesially for 9 days. Histological sections of the tooth were used to determine RR and tartrate resistant acid phosphatase (TRAP) activity. The Wilcoxon ranked-sum non-parametric test was used to evaluate differences between the groups. The results showed that the DBA/2J, BALB/cJ, and 129P3/J inbred mouse strains are highly susceptible to RR, whereas A/J, C57BL/6J and SJL/J mice are much more resistant. The variation in the severity of RR associated with orthodontic force among different inbred strains of mice when age, gender, food, housing, and orthodontic force magnitude/duration are controlled support the hypothesis that susceptibility or resistance to RR associated with orthodontic force is a genetically influenced trait.
ISSN:0141-5387
1460-2210
DOI:10.1093/ejo/cji090