Relationship between antinuclear antibody and microalbuminuria in the general population: the Takahata study

Background Microalbuminuria, a marker of vascular damage, is associated with increased risk of progressive renal deterioration, cardiovascular disease and mortality. However, the relationship between antinuclear antibody (ANA) and microalbuminuria in the general population is unknown. Thus, we condu...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental nephrology 2008-06, Vol.12 (3), p.200-206
Main Authors: Ishikawa, Mizue, Konta, Tsuneo, Hao, Zhimei, Takasaki, Satoshi, Abiko, Hiroshi, Takahashi, Toshiyuki, Ikeda, Ami, Ichikawa, Kazunobu, Shibata, Yoko, Takeishi, Yasuchika, Kato, Takeo, Kawata, Sumio, Kubota, Isao
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Albuminuria - blood
Albuminuria - diagnosis
Albuminuria - urine
Antibodies, Antinuclear - blood
Biomarkers - blood
Creatinine - urine
Cross-Sectional Studies
Female
Glomerular Filtration Rate
Humans
Japan
Male
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Original Article
Prevalence
Regression Analysis
Sex Characteristics
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Microalbuminuria, a marker of vascular damage, is associated with increased risk of progressive renal deterioration, cardiovascular disease and mortality. However, the relationship between antinuclear antibody (ANA) and microalbuminuria in the general population is unknown. Thus, we conducted a cross-sectional study to examine the relationship between ANA and microalbuminuria. Methods The subjects of this community-based study were individuals over 40 years old in Takahata, Japan. The urine albumin–creatinine ratio (UACR) was calculated from a single-spot urine specimen collected in the morning. ANA was examined by enzyme immunoassay (EIA). Results Among the 2,875 subjects (mean age 63 years; men 1,276; women 1,599), positive ANA (ANA index ≥20.0) was detected in 16.9% of the total population (men 12.9%, women 20.3%) and the prevalence of positive ANA increased with age. The prevalence of microalbuminuria (UACR 30–300 mg/g), but not macroalbuminuria (UACR  > 300 mg/g), was significantly higher in the positive ANA group than the negative ANA group (24.1% vs. 16.0%, respectively, P  
ISSN:1342-1751
1437-7799
DOI:10.1007/s10157-008-0030-0