Persistent Neuroinvasive West Nile Virus Infection in an Immunocompromised Patient

A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were dete...

Full description

Saved in:
Bibliographic Details
Published in:Clinical infectious diseases 2006-03, Vol.42 (5), p.680-683
Main Authors: Penn, Robert G., Guarner, Jeannette, Sejvar, James J., Hartman, Herbert, McComb, Rodney D., Nevins, Diana L., Bhatnagar, Julu, Zaki, Sherif R.
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Antigens, Viral - isolation & purification
Biological and medical sciences
Blood transfusions
Brief Reports
Disease control
Encephalitis
Epidemiology
Fatal Outcome
Hospitalization
Hospitals
Humans
Immunocompromised Host - immunology
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulins
Immunoglobulins - therapeutic use
Immunopathology
Infections
Infectious diseases
Male
Medical sciences
Middle Aged
Monoclonal antibodies
Nervous system diseases
Public health
Reverse transcriptase polymerase chain reaction
RNA
RNA, Viral - isolation & purification
Testing
Tests
Tissues
West Nile Fever - drug therapy
West Nile Fever - immunology
West Nile virus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were detected. This patient's case raises important issues related to the diagnosis, pathogenesis, and possible treatment of persistent WNV infection.
ISSN:1058-4838
1537-6591
DOI:10.1086/500216