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Handle with care: targeting neutrophils in chronic obstructive pulmonary disease and severe asthma?
Summary Neutrophils play an important role in the pathogenesis of airway inflammation in both chronic obstructive pulmonary disease (COPD) and severe asthma. Currently available drugs have only limited effects on neutrophilic airway inflammation, particularily in COPD. Therefore, great efforts are u...
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| Published in: | Clinical and experimental allergy 2006-02, Vol.36 (2), p.142-157 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4938-77f689eba25db2da59589309d462514521b4ed843bbbe854d8b77fd798d4040f3 |
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| cites | cdi_FETCH-LOGICAL-c4938-77f689eba25db2da59589309d462514521b4ed843bbbe854d8b77fd798d4040f3 |
| container_end_page | 157 |
| container_issue | 2 |
| container_start_page | 142 |
| container_title | Clinical and experimental allergy |
| container_volume | 36 |
| creator | Beeh, K. M. Beier, J. |
| description | Summary
Neutrophils play an important role in the pathogenesis of airway inflammation in both chronic obstructive pulmonary disease (COPD) and severe asthma. Currently available drugs have only limited effects on neutrophilic airway inflammation, particularily in COPD. Therefore, great efforts are undertaken to address neutrophilic inflammation in chronic respiratory disorders, in particular COPD. This review summarizes the rationale for anti‐neutrophilic treatment in COPD and asthma and gives a critical overview of current developments in drug therapy. Moreover, unanswered questions and limitations of clinical trial design and choice of outcome parameters for proof‐of‐concept studies with novel anti‐neutrophilic drugs are discussed as well as potential safety issues. |
| doi_str_mv | 10.1111/j.1365-2222.2006.02418.x |
| format | article |
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Neutrophils play an important role in the pathogenesis of airway inflammation in both chronic obstructive pulmonary disease (COPD) and severe asthma. Currently available drugs have only limited effects on neutrophilic airway inflammation, particularily in COPD. Therefore, great efforts are undertaken to address neutrophilic inflammation in chronic respiratory disorders, in particular COPD. This review summarizes the rationale for anti‐neutrophilic treatment in COPD and asthma and gives a critical overview of current developments in drug therapy. Moreover, unanswered questions and limitations of clinical trial design and choice of outcome parameters for proof‐of‐concept studies with novel anti‐neutrophilic drugs are discussed as well as potential safety issues.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.2006.02418.x</identifier><identifier>PMID: 16433851</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Allergic diseases ; Anti-Inflammatory Agents - therapeutic use ; Asthma - drug therapy ; Asthma - immunology ; Biological and medical sciences ; Chemotaxis, Leukocyte - drug effects ; Clinical Trials as Topic ; Drug Evaluation, Preclinical ; Enzyme Inhibitors - therapeutic use ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunopathology ; Leukocyte Rolling - drug effects ; Leukotriene Antagonists - therapeutic use ; Medical sciences ; Neutrophils - drug effects ; Pulmonary Disease, Chronic Obstructive - drug therapy ; Pulmonary Disease, Chronic Obstructive - immunology</subject><ispartof>Clinical and experimental allergy, 2006-02, Vol.36 (2), p.142-157</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Feb 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4938-77f689eba25db2da59589309d462514521b4ed843bbbe854d8b77fd798d4040f3</citedby><cites>FETCH-LOGICAL-c4938-77f689eba25db2da59589309d462514521b4ed843bbbe854d8b77fd798d4040f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17589227$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16433851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beeh, K. M.</creatorcontrib><creatorcontrib>Beier, J.</creatorcontrib><title>Handle with care: targeting neutrophils in chronic obstructive pulmonary disease and severe asthma?</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Summary
Neutrophils play an important role in the pathogenesis of airway inflammation in both chronic obstructive pulmonary disease (COPD) and severe asthma. Currently available drugs have only limited effects on neutrophilic airway inflammation, particularily in COPD. Therefore, great efforts are undertaken to address neutrophilic inflammation in chronic respiratory disorders, in particular COPD. This review summarizes the rationale for anti‐neutrophilic treatment in COPD and asthma and gives a critical overview of current developments in drug therapy. Moreover, unanswered questions and limitations of clinical trial design and choice of outcome parameters for proof‐of‐concept studies with novel anti‐neutrophilic drugs are discussed as well as potential safety issues.</description><subject>Allergic diseases</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Asthma - drug therapy</subject><subject>Asthma - immunology</subject><subject>Biological and medical sciences</subject><subject>Chemotaxis, Leukocyte - drug effects</subject><subject>Clinical Trials as Topic</subject><subject>Drug Evaluation, Preclinical</subject><subject>Enzyme Inhibitors - therapeutic use</subject><subject>Fundamental and applied biological sciences. 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M. ; Beier, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4938-77f689eba25db2da59589309d462514521b4ed843bbbe854d8b77fd798d4040f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Allergic diseases</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Asthma - drug therapy</topic><topic>Asthma - immunology</topic><topic>Biological and medical sciences</topic><topic>Chemotaxis, Leukocyte - drug effects</topic><topic>Clinical Trials as Topic</topic><topic>Drug Evaluation, Preclinical</topic><topic>Enzyme Inhibitors - therapeutic use</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Leukocyte Rolling - drug effects</topic><topic>Leukotriene Antagonists - therapeutic use</topic><topic>Medical sciences</topic><topic>Neutrophils - drug effects</topic><topic>Pulmonary Disease, Chronic Obstructive - drug therapy</topic><topic>Pulmonary Disease, Chronic Obstructive - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beeh, K. M.</creatorcontrib><creatorcontrib>Beier, J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beeh, K. M.</au><au>Beier, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Handle with care: targeting neutrophils in chronic obstructive pulmonary disease and severe asthma?</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2006-02</date><risdate>2006</risdate><volume>36</volume><issue>2</issue><spage>142</spage><epage>157</epage><pages>142-157</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary
Neutrophils play an important role in the pathogenesis of airway inflammation in both chronic obstructive pulmonary disease (COPD) and severe asthma. Currently available drugs have only limited effects on neutrophilic airway inflammation, particularily in COPD. Therefore, great efforts are undertaken to address neutrophilic inflammation in chronic respiratory disorders, in particular COPD. This review summarizes the rationale for anti‐neutrophilic treatment in COPD and asthma and gives a critical overview of current developments in drug therapy. Moreover, unanswered questions and limitations of clinical trial design and choice of outcome parameters for proof‐of‐concept studies with novel anti‐neutrophilic drugs are discussed as well as potential safety issues.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16433851</pmid><doi>10.1111/j.1365-2222.2006.02418.x</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-7894 |
| ispartof | Clinical and experimental allergy, 2006-02, Vol.36 (2), p.142-157 |
| issn | 0954-7894 1365-2222 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70731840 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Allergic diseases Anti-Inflammatory Agents - therapeutic use Asthma - drug therapy Asthma - immunology Biological and medical sciences Chemotaxis, Leukocyte - drug effects Clinical Trials as Topic Drug Evaluation, Preclinical Enzyme Inhibitors - therapeutic use Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunopathology Leukocyte Rolling - drug effects Leukotriene Antagonists - therapeutic use Medical sciences Neutrophils - drug effects Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - immunology |
| title | Handle with care: targeting neutrophils in chronic obstructive pulmonary disease and severe asthma? |
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